| Long-term opioid blockade and hedonic response: preliminary data from two open-label extension studies with extended-release naltrexone. | |
| | |
MedLine Citation:
|
PMID: 21314752 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The emergence of extended-release naltrexone (XR-NTX) raises the opportunity to explore the role of endorphin blockade on hedonic response during long-term alcohol dependence treatment. A hedonic survey was administered to 74 alcohol dependent patients treated for an average of 3.5 years with nearly continuous month-long intramuscular XR-NTX. The paper-and-pencil, one-time survey asked patients about the degree of pleasure they experienced in the past 90 days with drinking alcohol, sex, exercise and other daily activities. The data revealed lower pleasure ratings for alcohol than for sex, exercise and 10 other common activities. Mean responses to drinking alcohol and gambling were significantly lower than to listening to music, sex, reading, being with friends, eating good food, eating spicy food, and playing video/card games. This effect was independent of XR-NTX dose or duration. Although this exploratory study lacked baseline data, a comparison group or control for the impact of patient discontinuation, the data indicate the feasibility of examining long-term hedonic response in recovery. The differential hedonic ratings suggest that, in patients who persist with long-term continuous therapy, XR-NTX may selectively inhibit the pleasure associated with drinking alcohol, compared to a variety of other activities. (Am J Addict 2010;00: 1-7). |
| | |
Authors:
|
Charles P O'Brien; David R Gastfriend; Robert F Forman; Edward Schweizer; Helen M Pettinati |
Publication Detail:
|
Type: Journal Article Date: 2010-12-28 |
Journal Detail:
|
Title: The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions Volume: 20 ISSN: 1521-0391 ISO Abbreviation: Am J Addict Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9208821 Medline TA: Am J Addict Country: England |
Other Details:
|
Languages: eng Pagination: 106-12 Citation Subset: IM |
Copyright Information:
|
© American Academy of Addiction Psychiatry. |
Affiliation:
|
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Alkermes, Waltham, Massachusetts Paladin Consulting Group, Hoboken, New Jersey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The impact of drug use in social networks of patients with substance use and bipolar disorders.
Next Document: Anxiety sensitivity as a mediator of the relationship between moderate-intensity exercise and coping...