Document Detail

Long-term opioid blockade and hedonic response: preliminary data from two open-label extension studies with extended-release naltrexone.
MedLine Citation:
PMID:  21314752     Owner:  NLM     Status:  MEDLINE    
The emergence of extended-release naltrexone (XR-NTX) raises the opportunity to explore the role of endorphin blockade on hedonic response during long-term alcohol dependence treatment. A hedonic survey was administered to 74 alcohol dependent patients treated for an average of 3.5 years with nearly continuous month-long intramuscular XR-NTX. The paper-and-pencil, one-time survey asked patients about the degree of pleasure they experienced in the past 90 days with drinking alcohol, sex, exercise and other daily activities. The data revealed lower pleasure ratings for alcohol than for sex, exercise and 10 other common activities. Mean responses to drinking alcohol and gambling were significantly lower than to listening to music, sex, reading, being with friends, eating good food, eating spicy food, and playing video/card games. This effect was independent of XR-NTX dose or duration. Although this exploratory study lacked baseline data, a comparison group or control for the impact of patient discontinuation, the data indicate the feasibility of examining long-term hedonic response in recovery. The differential hedonic ratings suggest that, in patients who persist with long-term continuous therapy, XR-NTX may selectively inhibit the pleasure associated with drinking alcohol, compared to a variety of other activities. 
Charles P O'Brien; David R Gastfriend; Robert F Forman; Edward Schweizer; Helen M Pettinati
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-28
Journal Detail:
Title:  The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions     Volume:  20     ISSN:  1521-0391     ISO Abbreviation:  Am J Addict     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-06-06     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9208821     Medline TA:  Am J Addict     Country:  England    
Other Details:
Languages:  eng     Pagination:  106-12     Citation Subset:  IM    
Copyright Information:
© American Academy of Addiction Psychiatry.
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MeSH Terms
Alcoholism / drug therapy,  psychology*
Delayed-Action Preparations / therapeutic use
Middle Aged
Naltrexone / administration & dosage,  therapeutic use*
Narcotic Antagonists / administration & dosage,  therapeutic use*
Pleasure / drug effects*
Randomized Controlled Trials as Topic
Grant Support
P60 DA005186-25/DA/NIDA NIH HHS
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Narcotic Antagonists; 5S6W795CQM/Naltrexone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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