Document Detail

Long-term ophthalmic outcome of low birth weight children with and without retinopathy of prematurity.
MedLine Citation:
PMID:  11773536     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A prospective study of retinopathy of prematurity (ROP) of 505 infants who weighed <1701 g at birth was undertaken in the mid-1980s. This cohort was traced at 10 to 12 years of age to determine how low birth weight alone and ROP might influence their ophthalmic outcome. METHODS: Outcome measures were 1) visual functions (visual acuity, contrast sensitivity, stereoacuity, perimetry, and color vision), 2) presence of strabismus, and 3), measurements of eye size and the dimensions of its components including refractive state. A total of 169 11-year-olds who were born at term were recruited as control subjects and examined under the same conditions. RESULTS: A total of 448 of the original cohort were traced, and 254 consented to a further examination. Compared with the control group, the follow-up cohort differed significantly with reduced visual functions and increased incidence of both myopia and strabismus. Compared with published data, eye size was smaller in the low birth weight cohort. To summarize the ophthalmic data, we defined ophthalmic morbidity as visual acuity below 0.0 log units or the presence of strabismus, myopia, color vision defect, or visual field defect. The rate of ophthalmic morbidity was 50.8% (n = 129/254) in the study cohort compared with 19.5% (n = 33/169) in the control group. The highest rate of ophthalmic morbidity was associated with severe ROP (stages 3/4), although those with no ROP had a less favorable outcome than the control group. CONCLUSION: This study shows that low birth weight children are at increased risk of visual impairments compared with children who are born at full term. Visual impairments are associated with low birth weight per se and severe ROP. Regressed mild ROP is only a risk factor for strabismus. The functional significance of these deficits is largely unknown.
Anna R O'Connor; Terence Stephenson; Ann Johnson; Michael J Tobin; Merrick J Moseley; Sonia Ratib; Yin Ng; Alistair R Fielder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  109     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-04     Completed Date:  2002-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12-8     Citation Subset:  AIM; IM    
Division of Child Health, University of Nottingham, Nottingham, United Kingdom.
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MeSH Terms
Case-Control Studies
Cohort Studies
Follow-Up Studies
Great Britain / epidemiology
Infant, Low Birth Weight*
Infant, Newborn
Prospective Payment Assessment Commission
Retinopathy of Prematurity / epidemiology*
Vision Disorders / epidemiology*
Visual Acuity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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