| Long term ocular and neurological involvement in severe congenital toxoplasmosis. | |
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MedLine Citation:
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PMID: 7626575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: This study was set up to determine the long term ocular and systemic sequelae in patients with severe congenital toxoplasmosis. METHODS: Cross sectional and retrospective study of 17 patients with severe congenital toxoplasmosis. RESULTS: In addition to chorioretinitis (100%), the most common abnormal ocular features were optic nerve atrophy (83%), visual acuity of less than 0.1 (85%), strabismus, and microphthalmos. In 50% of cases we observed iridic abnormalities and about 40% developed a cataract. Overt endocrinological disease, diagnosed in five of 15 patients, included panhypopituitarism (n = 2), gonadal failure with dwarfism (n = 1), precocious puberty with dwarfism and thyroid deficiency (n = 1), and diabetes mellitus and thyroid deficiency (n = 1). The observed endocrinological involvement was associated in all cases with obstructive hydrocephalus with a dilated third ventricle and optic nerve atrophy. CONCLUSION: The recognition of long term ocular, neurological, and endocrinological sequelae of congenital toxoplasmosis is important for medical management of these severely handicapped patients. |
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Authors:
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C Meenken; J Assies; O van Nieuwenhuizen; W G Holwerda-van der Maat; M J van Schooneveld; W J Delleman; G Kinds; A Rothova |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 79 ISSN: 0007-1161 ISO Abbreviation: Br J Ophthalmol Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-09-07 Completed Date: 1995-09-07 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 581-4 Citation Subset: IM |
Affiliation:
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Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chorioretinitis / etiology Cross-Sectional Studies Endocrine System Diseases / etiology Female Humans Hydrocephalus / etiology Male Microphthalmos / etiology Optic Atrophy / etiology Retrospective Studies Strabismus / etiology Toxoplasmosis, Cerebral / complications, congenital* Toxoplasmosis, Ocular / complications, congenital* Visual Acuity |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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