Document Detail

Long term ocular and neurological involvement in severe congenital toxoplasmosis.
MedLine Citation:
PMID:  7626575     Owner:  NLM     Status:  MEDLINE    
AIMS: This study was set up to determine the long term ocular and systemic sequelae in patients with severe congenital toxoplasmosis. METHODS: Cross sectional and retrospective study of 17 patients with severe congenital toxoplasmosis. RESULTS: In addition to chorioretinitis (100%), the most common abnormal ocular features were optic nerve atrophy (83%), visual acuity of less than 0.1 (85%), strabismus, and microphthalmos. In 50% of cases we observed iridic abnormalities and about 40% developed a cataract. Overt endocrinological disease, diagnosed in five of 15 patients, included panhypopituitarism (n = 2), gonadal failure with dwarfism (n = 1), precocious puberty with dwarfism and thyroid deficiency (n = 1), and diabetes mellitus and thyroid deficiency (n = 1). The observed endocrinological involvement was associated in all cases with obstructive hydrocephalus with a dilated third ventricle and optic nerve atrophy. CONCLUSION: The recognition of long term ocular, neurological, and endocrinological sequelae of congenital toxoplasmosis is important for medical management of these severely handicapped patients.
C Meenken; J Assies; O van Nieuwenhuizen; W G Holwerda-van der Maat; M J van Schooneveld; W J Delleman; G Kinds; A Rothova
Related Documents :
15209465 - Bilateral chronic anterior uveitis & neuro-ophthalmologic manifestations in a patient w...
10565515 - Achromatic and short-wavelength automated perimetry in patients with glaucomatous large...
3722505 - Ocular disturbances in vitiligo.
6978475 - The progression of the ocular abnormalities of herpes zoster. histopathologic observati...
11168085 - Monitoring plasma levels of ganciclovir in aids patients receiving oral ganciclovir as ...
6419925 - Peritonitis prevented in continuous ambulatory peritoneal dialysis by using the hong ko...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  79     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-09-07     Completed Date:  1995-09-07     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  581-4     Citation Subset:  IM    
Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chorioretinitis / etiology
Cross-Sectional Studies
Endocrine System Diseases / etiology
Hydrocephalus / etiology
Microphthalmos / etiology
Optic Atrophy / etiology
Retrospective Studies
Strabismus / etiology
Toxoplasmosis, Cerebral / complications,  congenital*
Toxoplasmosis, Ocular / complications,  congenital*
Visual Acuity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Retinal detachment and herpesvirus retinitis in patients with AIDS.
Next Document:  Compliance in amblyopia therapy: objective monitoring of occlusion.