| Long-term observations on the effect of polyadenylic acid in mice of different ages. | |
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MedLine Citation:
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PMID: 6884439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to better life performance, polyadenylic acid (poly (A) ) was given intraperitoneally to CBA/Ca mice for almost a two-year period. This substance, as one of the components of double-stranded polynucleotides (like poly A:U), is known to improve some immune responses of the aging organism. Five approaches (changes in body-weight, adaptation to cold stress, biological half-life of body proteins, mortality and pathology) were applied to test the effects of this substance on life performance. It was found that the beneficial effects of double-stranded polynucleotides cannot be mimicked by polyadenylic acid only, despite its anti-senescence effect, namely, it accelerates the apparent protein turnover, cf., biological half-life. Polyadenylic acid shortens life-expectancy (because of the higher mortality rate of mice). Possible mechanisms of these actions are discussed. |
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Authors:
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L Pénzes; E Beregi; O Regius |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental gerontology Volume: 18 ISSN: 0531-5565 ISO Abbreviation: Exp. Gerontol. Publication Date: 1983 |
Date Detail:
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Created Date: 1983-10-28 Completed Date: 1983-10-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 89-94 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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drug effects* Animals Body Temperature Regulation / drug effects Body Weight / drug effects Longevity / drug effects Male Mice Mice, Inbred CBA Poly A / pharmacology* Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 24937-83-5/Poly A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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