Document Detail


Long-term observations on the effect of polyadenylic acid in mice of different ages.
MedLine Citation:
PMID:  6884439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to better life performance, polyadenylic acid (poly (A) ) was given intraperitoneally to CBA/Ca mice for almost a two-year period. This substance, as one of the components of double-stranded polynucleotides (like poly A:U), is known to improve some immune responses of the aging organism. Five approaches (changes in body-weight, adaptation to cold stress, biological half-life of body proteins, mortality and pathology) were applied to test the effects of this substance on life performance. It was found that the beneficial effects of double-stranded polynucleotides cannot be mimicked by polyadenylic acid only, despite its anti-senescence effect, namely, it accelerates the apparent protein turnover, cf., biological half-life. Polyadenylic acid shortens life-expectancy (because of the higher mortality rate of mice). Possible mechanisms of these actions are discussed.
Authors:
L Pénzes; E Beregi; O Regius
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental gerontology     Volume:  18     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / drug effects*
Animals
Body Temperature Regulation / drug effects
Body Weight / drug effects
Longevity / drug effects
Male
Mice
Mice, Inbred CBA
Poly A / pharmacology*
Proteins / metabolism
Chemical
Reg. No./Substance:
0/Proteins; 24937-83-5/Poly A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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