| Long-term observation of the perinuclear anti-neutrophil cytoplasmic antibody status in ulcerative colitis patients. | |
| | |
MedLine Citation:
|
PMID: 9517528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) have been regarded as a possible immunogenetic marker of ulcerative colitis. If this were true, the p-ANCA status of a given patient should be constant over time; however, little information is available on this issue. METHODS: One hundred and forty-five sera collected from 40 ulcerative colitis patients during a mean follow-up period of 50.6 months were tested for p-ANCA reactivity by indirect immunofluorescence. RESULTS: At base line 24 patients (60%) were p-ANCA-positive, with no relationship to gender distribution, age at diagnosis, disease activity, or extension. During follow-up, changes in p-ANCA status occurred in 10 patients (25%). P-ANCA positivity during follow-up was associated with more aggressive forms of disease, whereas p-ANCA negativity was associated with stable remission. CONCLUSIONS: Changes in the p-ANCA status over time occur in some ulcerative colitis patients. P-ANCA behaviour is associated with different clinical patterns of disease. |
| | |
Authors:
|
M Vecchi; M B Bianchi; C Calabresi; G Meucci; M Tatarella; R de Franchis |
Related Documents
:
|
21577198 - Acute aortic dissection in a patient with extremely low body mass index due to anorexia... 21713328 - A comparison of the original and simplified pulmonary embolism severity index. 22277088 - Clinically significant variability of serum ige concentrations in patients with severe ... 19086278 - Clinical features of microscopic colitis in a nation-wide follow-up study in iceland. 20797558 - Hydrogen sulfide, the third gaseous signaling molecule with cardiovascular properties, ... 10980058 - Targeted prophylaxis with amphotericin b lipid complex in liver transplantation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology Volume: 33 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1998 Feb |
Date Detail:
|
Created Date: 1998-05-12 Completed Date: 1998-05-12 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 170-3 Citation Subset: IM |
Affiliation:
|
Dept. of Gastroenterology and Digestive Endoscopy, Institute of Internal Medicine, University of Milan, IRCCS Ospedale Policlinico di Milano, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Antibodies, Antineutrophil Cytoplasmic / blood* Colitis, Ulcerative / immunology*, pathology Female Fluorescent Antibody Technique, Indirect Humans Longitudinal Studies Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Antineutrophil Cytoplasmic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased luminal nitric oxide in inflammatory bowel disease as shown with a novel minimally invasiv...
Next Document: Oxazolone-induced colitis in rats: effects of budesonide, cyclosporin A, and 5-aminosalicylic acid.