Document Detail

Long-term neuropsychological safety of subgenual cingulate gyrus deep brain stimulation for treatment-resistant depression.
MedLine Citation:
PMID:  24763760     Owner:  NLM     Status:  In-Data-Review    
Deep brain stimulation (DBS) of the subgenual cingulate gyrus (SCG) is a promising investigational intervention for treatment-resistant depression (TRD), but long-term outcome data are limited. Serial neuropsychological evaluations, using a comprehensive battery, were conducted on four subjects with TRD prior to surgery, and up to 42 months post-operatively. Reliable change methodology suggested general stability and/or select statistically reliable improvement in cognitive abilities over time. This is the first known set of multi-year neuropsychological follow-up data for SCG DBS for TRD. Observed improvements are likely attributable to reduced depressive symptomatology, recovery of functional capacities, and/or specific practice effects of repeated assessment.
Nicholas M Bogod; Marci Sinden; Cindy Woo; Vanessa G Defreitas; Ivan J Torres; Andrew K Howard; Magdalena I Ilcewicz-Klimek; Christopher R Honey; Lakshmi N Yatham; Raymond W Lam
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of neuropsychiatry and clinical neurosciences     Volume:  26     ISSN:  1545-7222     ISO Abbreviation:  J Neuropsychiatry Clin Neurosci     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911344     Medline TA:  J Neuropsychiatry Clin Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  126-33     Citation Subset:  IM    
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