Document Detail

Long-term neurodevelopmental outcome of triplets.
MedLine Citation:
PMID:  17223247     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyze the incidence of neurodevelopmental disabilities in triplets and to find out possible connection between the outcome and perinatal events. DESIGN: Retrospective cohort study of 94 triplets and their outcome at 24-144 months of age correlated with gestational age, birth weight, pregnancy complications, early neonatal period, neonatal cranial ultrasound, period of birth (1985-1995, 1996-2000) and type of antenatal care. RESULTS: Sixty-two triplets are healthy, 15 suffer cerebral palsy (CP) and 17 minimal cerebral dysfunction (MCD). Adverse outcome correlates significantly with prematurity, low birth weight and maternal age. In multivariate analysis, both cerebral palsy and minor disabilities correlate significantly with early neonatal complications, neonatal cranial ultrasound with later CP (p<0.01), and MCD with preterm rupture of membranes (p=0.047). Children conceived spontaneously do worse than those born after assisted reproduction (p=0.004), those born in the time period 1996-2000 do better than those born before (p=0.021). Seventy-seven percent (77%) of newborns delivered in the time period 1996-2000 and after level 1 antenatal care was introduced, compared with 54% being delivered in the time period before 1996 and with less meticulous types of antenatal care, remain healthy (p=0.015). CONCLUSION: Triplets are still at high risk for long-term neurodevelopmental complications. Stringent perinatal care might appear important determinant of their long-term outcome.
Snjezana Skrablin; Ivan Kuvacić; Velimir Simunić; Katarina Bosnjak-Nadj; Drzislav Kalafatić; Vladimir Banović
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Publication Detail:
Type:  Journal Article     Date:  2007-01-16
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  132     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  76-82     Citation Subset:  IM    
Department of Perinatal Medicine, School of Medicine, Petrova 13, 10000 Zagreb, Croatia.
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MeSH Terms
Birth Weight
Brain Damage, Chronic / epidemiology*
Cerebral Palsy / epidemiology*
Child, Preschool
Cohort Studies
Fertilization in Vitro
Fetal Development*
Gestational Age
Infant, Newborn
Maternal Age
Pregnancy Complications
Prenatal Care
Retrospective Studies
Triplets / physiology*
Ultrasonography, Prenatal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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