Document Detail


Long-term neurodevelopmental outcome after intrauterine laser treatment for severe twin-twin transfusion syndrome.
MedLine Citation:
PMID:  12712079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to investigate long-term neurodevelopmental outcome after intrauterine laser treatment for twin-twin transfusion syndrome. STUDY DESIGN: All 89 surviving infants who were treated between January 1995 and May 1997 were investigated in a single center. Seventy-five children were tested with the Griffiths' Developmental Test Scales at a median age of 21 months; 14 children (median age, 34 months) were tested with the Snijders-Oomen-Non-Verbal-Intelligence Test. All children underwent a detailed standardized physical and neurologic examination. RESULTS: Sixty-nine infants (78%) showed a normal development (group I), 10 infants (11%) had minor neurologic deficiencies (group II), and 10 infants (11%) had major neurologic deficiencies (group III). No difference between recipient and donor status was observed (P =.93). There was a trend toward a more favorable outcome for those infants who were born as twins (53 infants [81%] in group I and 5 infants [8%] in group III) compared with singleton survivors after intrauterine death of the cotwin (16 infants [67%] in group I and 5 infants [21%] in group III); however, the difference was not significant (P =.12). CONCLUSION: After intrauterine laser treatment for twin-twin transfusion syndrome, 78% of the children had a normal neurodevelopmental status, 11% of the children had minor neurologic deficiencies, and 11% of the children had major neurologic deficiencies, at a median age of 22 months.
Authors:
Corinna S Banek; Kurt Hecher; Bernhard J Hackeloer; Peter Bartmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  188     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-24     Completed Date:  2003-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  876-80     Citation Subset:  AIM; IM    
Affiliation:
Department of Neonatology, University Children's Hospital, Bonn, Germany.
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MeSH Terms
Descriptor/Qualifier:
Child Development*
Child, Preschool
Female
Fetal Death / complications
Fetofetal Transfusion / complications*,  surgery*
Humans
Infant
Laser Coagulation*
Longitudinal Studies
Nervous System / growth & development*
Nervous System Diseases / etiology*,  physiopathology
Pregnancy
Severity of Illness Index
Comments/Corrections
Comment In:
Am J Obstet Gynecol. 2004 Apr;190(4):1170-1; author reply 1171-2   [PMID:  15132156 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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