| Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin. | |
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MedLine Citation:
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PMID: 19394042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the effects of nausea and vomiting of pregnancy (NVP) and its treatment with diclectin on child neurodevelopment. STUDY DESIGN: An observational cohort study of mother-child pairs ascertained via a pregnancy call-in center was conducted. Three groups of children were studied: 45 with NVP and diclectin, 47 with NVP no diclectin, and 29 with no NVP. Phone calls to mothers during pregnancy and 6 to 9 months after childbirth yielded information on pregnancy, birth, and early child development. Children aged 3 to 7 years received a comprehensive set of psychological tests. Mothers were assessed for IQ and socioeconomic status. RESULTS: All children scored in the normal range for IQ, with the NVP-exposed group scoring higher than the non-exposed group on Performance IQ (P < .02), NEPSY Verbal Fluency (P < .003) and Phonological Processing (P < .004), and McCarthy Numerical Memory (P < .004). Predictors of enhanced results were NVP severity and maternal IQ. CONCLUSIONS: NVP has an enhancing effect on later child outcome. Diclectin does not appear to adversely affect fetal brain development and can be used to control NVP when clinically indicated. |
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Authors:
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Irena Nulman; Joanne Rovet; Maru Barrera; Dafna Knittel-Keren; Brian M Feldman; Gideon Koren |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-24 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 155 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-29 Completed Date: 2009-07-22 Revised Date: 2009-10-16 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 45-50, 50.e1-2 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada. inulman@sickkids.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiemetics / therapeutic use* Child Child Development Child, Preschool Cohort Studies Doxylamine / therapeutic use Drug Combinations Female Humans Intelligence* Intelligence Tests Linear Models Maternal-Fetal Exchange Nausea / drug therapy* Pregnancy Pregnancy Complications / drug therapy* Pyridoxine / therapeutic use Severity of Illness Index Sleep Vomiting / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antiemetics; 0/Drug Combinations; 0/doxylamine, pyridoxine drug combination; 469-21-6/Doxylamine; 65-23-6/Pyridoxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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