| Long-term nasal continuous positive airway pressure treatment lowers blood pressure in patients with obstructive sleep apnea regardless of age. | |
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MedLine Citation:
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PMID: 20668457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effective treatment with nasal continuous positive airway pressure (nCPAP) lowers blood pressure (BP) in patients with obstructive sleep apnea (OSA). It was reported that OSA might influence BP in middle-aged but not in elderly patients. However, effects of nCPAP treatment in elderly hypertensive OSA patients are not well known. We investigated long-term compliance with nCPAP and its effects on BP in elderly and middle-aged OSA patients. This observational study involved 92 OSA patients (81 men, 11 women; 46 middle-aged, 46 elderly; body mass index (BMI), 27.7 (27.0-28.7) kg m(-2); apnea hypopnea index, 43.0 (39.4-46.6) per h; 95% confidence intervals). BP and BMI were measured before the study and at two checkpoints after usage of nCPAP (616 (553-679) and 1048 (985-1114) days). Diastolic BP decreased by 5.69 (3.09-8.29) mm Hg after 600 days of nCPAP treatment and by 4.50 (1.80-7.19) mm Hg after 1000 days (P=0.003). There were no significant changes in systolic BP, BMI or usage time of nCPAP. With a daily average of 3 h or more of nCPAP treatment, diastolic BP decreased significantly in subject groups ≥ 60 and <60 years of age. Even in the elderly, a daily average use of nCPAP for 3 h would lower diastolic BP in OSA patients. |
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Authors:
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Kensaku Aihara; Kazuo Chin; Toru Oga; Ken-ichi Takahashi; Takefumi Hitomi; Misa Takegami; Tomohiro Handa; Akio Niimi; Tomomasa Tsuboi; Michiaki Mishima |
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Publication Detail:
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Type: Journal Article Date: 2010-07-29 |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 33 ISSN: 1348-4214 ISO Abbreviation: Hypertens. Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: England |
Other Details:
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Languages: eng Pagination: 1025-31 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aging / physiology* Antihypertensive Agents / therapeutic use Blood Pressure / physiology* Body Mass Index Cohort Studies Continuous Positive Airway Pressure* Female Humans Hypertension / etiology, physiopathology*, therapy* Longitudinal Studies Male Middle Aged Patient Compliance Retrospective Studies Sleep Apnea, Obstructive / complications, physiopathology*, therapy* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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