Document Detail


Long-term morbidity in total colonic aganglionosis.
MedLine Citation:
PMID:  9694078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/PURPOSE: No surgical treatment for total colonic aganglionosis (TCA) clearly has been proven superior. To identify clinical criteria associated with long-term functional outcome, a 28-year retrospective institutional review of this entity from 1969 through 1996 inclusive was undertaken. METHODS: Total colonic aganglionosis (TCA), defined here as aganglionosis extending from the anus to at least the ileocecal valve but no further than 50 cm proximal to the ileocecal valve, was identified in 29 infants and children. Appropriate leveling ileostomy was performed in 28 of 29 patients, and definitive surgical reconstruction was performed in 26 of 29. Three groups were identified based on the definitive surgical repair performed: group 1, construction lacking or incorporating a short ganglionic-aganglionic common channel (modified Soave or modified Duhamel, n = 8); group II, construction of an extended common channel (Martin-Duhamel, Martin-Soave; n = 6); and group III, all others including an intermediate-length common channel (n = 13). RESULTS: Functional outcome at extended follow-up (mean, 6.6 +/- 5.6 years; range, 0.7 to 23) was determined based on survival, long-term ostomy requirements, growth, major complications, continence, and enterocolitis and bowel movement frequency. Although long-term functional outcome was deemed satisfactory in six of seven patients in group I, function was satisfactory in none of six group II patients. Group III results were intermediate (satisfactory in 6 of 13). CONCLUSIONS: Acceptable long-term outcome was most frequent in TCA patients whose definitive repair did not incorporate an extended ganglionic-aganglionic common channel. The use of extensive lengths of aganglionic bowel to maximize fluid absorption is frequently met with substantial morbidity.
Authors:
J C Hoehner; S H Ein; B Shandling; P C Kim
Related Documents :
17394048 - Mechanical bowel preparation for elective colorectal surgery with primary intraperitone...
3337628 - Pseudomonas cepacia-associated pneumonia in cystic fibrosis. relation of clinical featu...
6339598 - Myxedema megacolon after external neck irradiation.
21785918 - Optimal size of jejunal pouch as a reservoir after total gastrectomy: a single-center p...
21029818 - Validation of long-term benefits of bivalirudin versus unfractionated heparin in routin...
23780568 - Clostridium difficile colitis acquired in the intensive care unit: outcome and prognost...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  33     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-10-22     Completed Date:  1998-10-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  961-5; discussion 965-6     Citation Subset:  IM    
Affiliation:
Division of General Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Birth Weight
Child, Preschool
Female
Gestational Age
Hirschsprung Disease / mortality,  surgery*
Humans
Infant
Infant, Newborn
Male
Postoperative Complications
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A defective retroviral vector encoding human interferon-alpha2 can transduce human leukemic cell lin...
Next Document:  Long-term follow-up after bowel resection for necrotizing enterocolitis: factors affecting outcome.