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Long-term molecular remission with lenalidomide treatment of relapsed chronic lymphocytic leukemia.
MedLine Citation:
PMID:  23281656     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Lenalidomide is effective against relapsed chronic lymphocytic leukemia (CLL). We report the first case of long-term molecular remission with continuous lenalidomide treatment in a young patient with CLL relapsed to multiple treatments. Minimal residual disease was assessed by nested polymerase chain reaction on bone marrow samples with patient-specific primers. A 20-year-old patient with standard-risk CLL was treated with lenalidomide after multiple relapses and achieved a four year long complete molecular response with minimal toxicities. Published biologic data support that lenalidomide induces an immune-mediated control of CLL, and our case suggests that long-term treatment with lenalidomide is effective at a molecular level in patients with relapsed CLL. © 2013 John Wiley & Sons A/S.
Authors:
Francesco Spina; Francesca Rezzonico; Lucia Farina; Paolo Corradini
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-2
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Affiliation:
Division of Hematology-Bone Marrow Transplatation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
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