Document Detail


Long-term modulation of respiratory network activity following anoxia in vitro.
MedLine Citation:
PMID:  12037199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neural networks that produce rhythmic behaviors require flexibility to respond to changes in the internal and external state of the animal. It is important to not only understand how a network responds during such perturbations but also how the network recovers. For example, the respiratory network needs to respond to and recover from temporary changes in oxygen level that can occur during sleep, exercise, and respiratory disorders. During a temporary decrease in oxygen level, there is an increase in respiratory frequency followed by a depression that can lead to complete apnea. Here we used a mouse brain stem slice preparation as a model system to examine the recovery of respiratory network activity after brief episodes of anoxia. We found the respiratory network recovers from a single anoxic episode with a transient increase in fictive respiratory frequency. Although repetitive anoxia does not elicit a greater frequency increase, it does elicit a longer lasting frequency increase persisting < or =90 min. Thus there is a centrally mediated long-lasting influence on the respiratory network elicited by decreased oxygen levels. This modulation occurs as a prolonged facilitation of fictive respiratory frequency after brief repetitive but not single anoxic exposure. These data are important to consider in the context of disorders such as sleep apnea in which brief periodic anoxic episodes are experienced.
Authors:
Dawn M Blitz; Jan-Marino Ramirez
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurophysiology     Volume:  87     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-30     Completed Date:  2002-08-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2964-71     Citation Subset:  IM    
Affiliation:
Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Female
Hypoxia, Brain / physiopathology*
Male
Mice
Mice, Inbred Strains
Organ Culture Techniques
Periodicity
Recovery of Function / physiology
Respiratory Center / physiopathology*
Respiratory Mechanics / physiology*
Grant Support
ID/Acronym/Agency:
F32-HL-10168/HL/NHLBI NIH HHS; R01-HL-60120/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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