Document Detail

Long-term minocycline use for acne in healthy adolescents can cause severe autoimmune hepatitis.
MedLine Citation:
PMID:  19262406     Owner:  NLM     Status:  MEDLINE    
Over the years, a variety of abnormal immune reactions to minocycline have been reported including arthritis, systemic lupus erythematosus, and hepatitis. The current report describes the detailed clinical and pathologic features of 3 patients who presented with chronic/autoimmune hepatitis alone while on minocycline at our hospital over a 2-year period. Minocycline use in these patients was temporally related to onset of severe hepatitis. Adolescents with such a reaction to minocycline have been included in previous reports but have not been well described as a distinct entity. We have compared our cases with similar cases previously reported with a review of the literature and a discussion of the implications for prescribing physicians.
Jyoti Ramakrishna; Amy R Johnson; Barbara F Banner
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  43     ISSN:  1539-2031     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-20     Completed Date:  2009-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  787-90     Citation Subset:  IM    
Pediatric Gastroenterology and Nutrition, Department of Pediatrics, UMass Medical School/UMMHC, Worcester, MA 01655, USA.
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MeSH Terms
Acne Vulgaris / drug therapy*
Anti-Bacterial Agents / adverse effects*,  therapeutic use
Drug-Induced Liver Injury, Chronic / etiology*,  physiopathology
Hepatitis, Autoimmune / etiology*,  physiopathology
Minocycline / adverse effects*,  therapeutic use
Severity of Illness Index
Reg. No./Substance:
0/Anti-Bacterial Agents; 10118-90-8/Minocycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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