| Long-term minocycline use for acne in healthy adolescents can cause severe autoimmune hepatitis. | |
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MedLine Citation:
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PMID: 19262406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over the years, a variety of abnormal immune reactions to minocycline have been reported including arthritis, systemic lupus erythematosus, and hepatitis. The current report describes the detailed clinical and pathologic features of 3 patients who presented with chronic/autoimmune hepatitis alone while on minocycline at our hospital over a 2-year period. Minocycline use in these patients was temporally related to onset of severe hepatitis. Adolescents with such a reaction to minocycline have been included in previous reports but have not been well described as a distinct entity. We have compared our cases with similar cases previously reported with a review of the literature and a discussion of the implications for prescribing physicians. |
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Authors:
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Jyoti Ramakrishna; Amy R Johnson; Barbara F Banner |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 43 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-20 Completed Date: 2009-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 787-90 Citation Subset: IM |
Affiliation:
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Pediatric Gastroenterology and Nutrition, Department of Pediatrics, UMass Medical School/UMMHC, Worcester, MA 01655, USA. ramakrij@ummhc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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drug therapy* Adolescent Anti-Bacterial Agents / adverse effects*, therapeutic use Drug-Induced Liver Injury, Chronic / etiology*, physiopathology Female Hepatitis, Autoimmune / etiology*, physiopathology Humans Male Minocycline / adverse effects*, therapeutic use Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 10118-90-8/Minocycline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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