Document Detail

Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers.
MedLine Citation:
PMID:  17532034     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cession of heroin use may be followed by a protracted-abstinence (PA) syndrome consisting of craving, negative mood, and physiological changes. PA symptoms have rarely been compared between drug-free and methadone-maintained former heroin users after similar lengths of heroin abstinence. METHODS: Seventy former heroin users were included in one of four groups: in day 15-45 of methadone maintenance therapy (short-term MMT), in month 5-6 of MMT (long-term MMT), opiate-free for 15-45 days after methadone-assisted heroin detoxification (short-term post-methadone), and opiate-free for 5-6 months after methadone-assisted heroin detoxification (long-term post-methadone). PA symptoms (negative mood, dyssomnia, somatization, and craving), and blood pressure and pulse were assessed pre- and post-neutral videotape and pre- and post-heroin videotape. RESULTS: Dyssomnia and the total PA score were worst in short-term post-methadone participants, mood was best in long-term MMT participants, and cue-induced craving was least severe in long-term MMT participants. Blood pressure and pulse did not differ across groups. CONCLUSIONS: Even after acute withdrawal, the first months of heroin abstinence after methadone-assisted detoxification may be more difficult in terms of cue-induced craving and other PA symptoms than the first months of heroin abstinence during MMT. Our findings add to the literature supporting MMT for prevention of cue-induced heroin craving.
Jie Shi; Li-Yan Zhao; David H Epstein; Xiao-Li Zhang; Lin Lu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-21
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  87     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-06-08     Completed Date:  2007-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Department of Clinical Pharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China.
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MeSH Terms
Blood Pressure / drug effects
Heart Rate / drug effects
Heroin Dependence / psychology*,  rehabilitation*
Methadone / therapeutic use*
Mood Disorders / etiology,  psychology
Narcotics / therapeutic use*
Photic Stimulation
Sleep Disorders / etiology,  psychology
Somatoform Disorders / etiology,  psychology
Substance Withdrawal Syndrome / psychology*
Reg. No./Substance:
0/Narcotics; 76-99-3/Methadone

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