| Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers. | |
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MedLine Citation:
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PMID: 17532034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cession of heroin use may be followed by a protracted-abstinence (PA) syndrome consisting of craving, negative mood, and physiological changes. PA symptoms have rarely been compared between drug-free and methadone-maintained former heroin users after similar lengths of heroin abstinence. METHODS: Seventy former heroin users were included in one of four groups: in day 15-45 of methadone maintenance therapy (short-term MMT), in month 5-6 of MMT (long-term MMT), opiate-free for 15-45 days after methadone-assisted heroin detoxification (short-term post-methadone), and opiate-free for 5-6 months after methadone-assisted heroin detoxification (long-term post-methadone). PA symptoms (negative mood, dyssomnia, somatization, and craving), and blood pressure and pulse were assessed pre- and post-neutral videotape and pre- and post-heroin videotape. RESULTS: Dyssomnia and the total PA score were worst in short-term post-methadone participants, mood was best in long-term MMT participants, and cue-induced craving was least severe in long-term MMT participants. Blood pressure and pulse did not differ across groups. CONCLUSIONS: Even after acute withdrawal, the first months of heroin abstinence after methadone-assisted detoxification may be more difficult in terms of cue-induced craving and other PA symptoms than the first months of heroin abstinence during MMT. Our findings add to the literature supporting MMT for prevention of cue-induced heroin craving. |
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Authors:
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Jie Shi; Li-Yan Zhao; David H Epstein; Xiao-Li Zhang; Lin Lu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-21 |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 87 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-06-08 Completed Date: 2007-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 141-5 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects China Cues* Heart Rate / drug effects Heroin Dependence / psychology*, rehabilitation* Humans Male Methadone / therapeutic use* Mood Disorders / etiology, psychology Narcotics / therapeutic use* Photic Stimulation Sleep Disorders / etiology, psychology Somatoform Disorders / etiology, psychology Substance Withdrawal Syndrome / psychology* |
| Chemical | |
Reg. No./Substance:
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0/Narcotics; 76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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