Document Detail

Long-term management of exercise-induced myocardial ischemia. Diltiazem versus propranolol, a double-blind, crossover study.
MedLine Citation:
PMID:  3781675     Owner:  NLM     Status:  MEDLINE    
The authors performed a long-term, double-blind, crossover study on the effect of two drugs (propranolol, 40 mg t.i.d. or diltiazem, 60 mg t.i.d., each administered for 2 months) on their exercise tolerance in 13 patients with stable angina (mean age 52 +/- 7 years, 9 males and 4 females), after exertion and documented significant (greater than or equal to 70%) obstructive coronary lesions at angiography. Only propranolol, by decreasing heart rate and rate-pressure product, improved maximal sustained work load and duration of exercise (measured by a bicycle ergometer) versus the placebo (p less than 0.05). In both cases, however, they did not find any significant difference between propranolol and diltiazem. ST segment depression was decreased by both drugs (-1.73 +/- 0.95, baseline, vs -0.94 +/- 1.01, propranolol, and -0.95 +/- 0.76, diltiazem, p less than 0.5, for both). Long-term management of stable angina on effort therefore, can be usefully performed using propranolol or diltiazem.
M Romano; T di Maro; M R Cotecchia; G Carella; E de Arcangelis; M Clarizia; M Chiariello
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  24     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-30     Completed Date:  1986-12-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  551-4     Citation Subset:  IM    
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MeSH Terms
Coronary Disease / drug therapy*
Diltiazem / therapeutic use*
Double-Blind Method
Exercise Test
Heart Rate / drug effects
Middle Aged
Physical Exertion*
Propranolol / therapeutic use*
Reg. No./Substance:
42399-41-7/Diltiazem; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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