|Long-term maintenance of weight loss after lifestyle intervention in frail, obese older adults.|
|PMID: 23299370 Owner: NLM Status: MEDLINE|
|OBJECTIVES: To determine if long-term weight loss with associated improvement in physical and metabolic health can be maintained after lifestyle intervention in frail, obese older adults.
DESIGN: Thirty-month follow-up pilot study of a 1-year lifestyle intervention trial.
PARTICIPANTS: Sixteen frail, obese (body mass index=36±2 kg/m2) older (71±1 yr.) adults.
MEASUREMENTS: Body weight and composition, physical function, markers of the metabolic syndrome, glucose and insulin response to an oral glucose tolerance test, bone mineral density (BMD), liver and renal function tests, and food diaries.
RESULTS: At 30-month follow-up, weight (101.5±3.8 vs. 94.5±3.9 kg) and BMI (36.0 ±1.7 vs. 33.5±1.7 kg/m2) remained significantly below baseline (all p<0.05). No significant change in fat-free mass (56.7±2.1 vs. 56.9±2.2 kg) or appendicular lean mass (24.1±1.0 vs. 24.1±1.1kg, all p>0.05) occurred between 12 months (end of trial) and 30 months. Improvements in the physical performance test (PPT 27±0.7 vs. 30.2±0.6), insulin sensitivity (4.1±0.8 vs. 3.0±0.6), and insulin area under the curve (12484±2042 vs. 9270±1139 min.mg/dl) remained at 30 months compared to baseline (all p<0.05). Waist circumference (116±3 vs. 109±3 cm) and systolic blood pressure (134±6 vs. 123±5 mm HG) remained decreased at 30 months compared to baseline (all p<0.05). Whole body and lumbar spine BMD did not change; however, total hip BMD progressively decreased at 30 months compared to baseline (0.985±.026 vs. 0.941±.024 g/cm2; p<0.05). There were no adverse effects on liver or renal function. Food frequency questionnaire data showed lower overall caloric intake (-619±157 kcal/day) at 30 months compared to baseline (p<0.05).
CONCLUSION: These findings suggest that long-term maintenance of clinically important weight loss is possible in frail, obese older adults. Weight maintenance appears to be achieved through continued caloric restriction. Larger, long-term studies are needed to follow up on these findings and investigate mechanisms and behaviors underlying maintenance of weight loss and physical function.
|D L Waters; R Vawter; C Qualls; S Chode; R Armamento-Villareal; D T Villareal|
|Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't|
|Title: The journal of nutrition, health & aging Volume: 17 ISSN: 1760-4788 ISO Abbreviation: J Nutr Health Aging Publication Date: 2013 Jan|
|Created Date: 2013-01-09 Completed Date: 2013-06-28 Revised Date: 2014-01-09|
Medline Journal Info:
|Nlm Unique ID: 100893366 Medline TA: J Nutr Health Aging Country: France|
|Languages: eng Pagination: 3-7 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Body Mass Index
European Continental Ancestry Group
Glucose Tolerance Test
Insulin / blood
Metabolic Syndrome X / diet therapy*, physiopathology
Obesity / diet therapy*, physiopathology
Quality of Life
|DK20579/DK/NIDDK NIH HHS; P60 DK020579/DK/NIDDK NIH HHS; R01 AG025501/AG/NIA NIH HHS; R01 AG031176/AG/NIA NIH HHS; R01 AG31176/AG/NIA NIH HHS; R01-AG025501/AG/NIA NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1-RR024992/RR/NCRR NIH HHS|
|0/Blood Glucose; 0/Insulin|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term, High-resolution Confocal Time Lapse Imaging of Arabidopsis Cotyledon Epidermis during Ger...
Next Document: Malnutrition in elderly: social and economic determinants.