Document Detail

Long term lipid-based parenteral nutrition causes pulmonary hypertension in pigs.
MedLine Citation:
PMID:  8891624     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study pulmonary perfusion after long term intravenous lipid-based total parenteral nutrition (TPN). DESIGN: Open experimental study. SETTING: Teaching hospital, Norway. MATERIAL: 31 pigs. INTERVENTIONS: Infusion of TPN alone, TPN + pellets, or Ringer's solution alone through central venous catheters for 7 weeks. OUTCOME MEASURES: Haemodynamic variables during a standardised volume load, and measurement of plasma N-terminal pro-atrial natriuretic factor (ANF). RESULTS: Mean pulmonary artery pressure (PAP) was 12.9 (6.1) to 20.1 (3.0) mmHg in response to the volume load in control animals compared with 15.8 (8.5) to 25.4 (5.8) (p < 0.05) mmHg in those given TPN alone and 22.8 (10.3) (p < 0.05) to 28.0 (6.4) (p < 0.05) mmHg in those given TPN and pellets. Pulmonary vascular resistance index was also increased after TPN, but the plasma N-terminal pro-ANF concentration did not increase during infusion of TPN. CONCLUSION: Long term TPN caused moderate pulmonary hypertension, but not longstanding right-sided congestion.
J Aksnes; H Schmidt; C Hall; K Nordstrand
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European journal of surgery = Acta chirurgica     Volume:  162     ISSN:  1102-4151     ISO Abbreviation:  Eur J Surg     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-02-04     Completed Date:  1997-02-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9105264     Medline TA:  Eur J Surg     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  649-56     Citation Subset:  IM    
Institute for Surgical Research, National Hospital, University of Oslo, Norway.
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MeSH Terms
Atrial Natriuretic Factor / blood
Catheterization, Central Venous
Central Venous Pressure
Energy Intake
Fat Emulsions, Intravenous / adverse effects
Hypertension, Pulmonary / etiology*,  physiopathology
Linoleic Acid
Linoleic Acids / adverse effects
Parenteral Nutrition, Total / adverse effects*
Protein Precursors / blood
Pulmonary Wedge Pressure
Time Factors
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Linoleic Acids; 0/Protein Precursors; 2197-37-7/Linoleic Acid; 85637-73-6/Atrial Natriuretic Factor

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