| Long term lipid-based parenteral nutrition causes pulmonary hypertension in pigs. | |
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MedLine Citation:
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PMID: 8891624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study pulmonary perfusion after long term intravenous lipid-based total parenteral nutrition (TPN). DESIGN: Open experimental study. SETTING: Teaching hospital, Norway. MATERIAL: 31 pigs. INTERVENTIONS: Infusion of TPN alone, TPN + pellets, or Ringer's solution alone through central venous catheters for 7 weeks. OUTCOME MEASURES: Haemodynamic variables during a standardised volume load, and measurement of plasma N-terminal pro-atrial natriuretic factor (ANF). RESULTS: Mean pulmonary artery pressure (PAP) was 12.9 (6.1) to 20.1 (3.0) mmHg in response to the volume load in control animals compared with 15.8 (8.5) to 25.4 (5.8) (p < 0.05) mmHg in those given TPN alone and 22.8 (10.3) (p < 0.05) to 28.0 (6.4) (p < 0.05) mmHg in those given TPN and pellets. Pulmonary vascular resistance index was also increased after TPN, but the plasma N-terminal pro-ANF concentration did not increase during infusion of TPN. CONCLUSION: Long term TPN caused moderate pulmonary hypertension, but not longstanding right-sided congestion. |
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Authors:
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J Aksnes; H Schmidt; C Hall; K Nordstrand |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European journal of surgery = Acta chirurgica Volume: 162 ISSN: 1102-4151 ISO Abbreviation: Eur J Surg Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-02-04 Completed Date: 1997-02-04 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9105264 Medline TA: Eur J Surg Country: NORWAY |
Other Details:
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Languages: eng Pagination: 649-56 Citation Subset: IM |
Affiliation:
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Institute for Surgical Research, National Hospital, University of Oslo, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Natriuretic Factor / blood Catheterization, Central Venous Central Venous Pressure Energy Intake Fat Emulsions, Intravenous / adverse effects Hypertension, Pulmonary / etiology*, physiopathology Linoleic Acid Linoleic Acids / adverse effects Natriuresis Parenteral Nutrition, Total / adverse effects* Protein Precursors / blood Pulmonary Wedge Pressure Swine Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Fat Emulsions, Intravenous; 0/Linoleic Acids; 0/Protein Precursors; 2197-37-7/Linoleic Acid; 85637-73-6/Atrial Natriuretic Factor |
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