| Long-term intravesical oxybutynin chloride therapy in children with myelodysplasia. | |
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MedLine Citation:
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PMID: 8808907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We evaluated the clinical use of long-term intravesical oxybutynin chloride in the treatment of neurogenic bladder dysfunction in children with myelodysplasia who could not tolerate oral anticholinergics. MATERIALS AND METHODS: We retrospectively reviewed the records of all patients recommended for intravesical oxybutynin chloride therapy. A total of 12 girls and 18 boys 1 to 17 years old was recruited for study. Oxybutynin chloride (5 mg.) was instilled 2 times daily and pretreatment cystograms were compared to followup urodynamic studies. Duration of therapy was 2 to 26 months (mean 13, median 12). RESULTS: Mean total capacity plus or minus standard deviation increased from 209 +/- 103 to 282 +/- 148 ml. (p < 0.01), mean safe capacity increased from 157 +/- 105 to 234 +/- 147 ml. (p < 0.01) and mean age adjusted safe capacity increased from 76 +/- 36 to 115 +/- 62%. Of the 29 patients who were incontinent 3 (10%) achieved continence and 19 (65%) reported a decreased use of sanitary pads. None of the patients had systemic side effects related to intravesical treatment. CONCLUSIONS: We believe that intravesical oxybutynin chloride is a viable treatment option for patients with myelodysplasia in whom oral therapy fails. |
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Authors:
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K A Painter; T S Vates; T P Bukowski; P Fleming; A L Freedman; C A Smith; R Gonzalez; A D Perlmutter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of urology Volume: 156 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1996-11-07 Completed Date: 1996-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1459-62 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatric Urology, Children's Hospital of Michigan, Wayne State University, Detroit, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intravesical Adolescent Child Child, Preschool Female Humans Infant Male Mandelic Acids / administration & dosage* Neural Tube Defects / complications*, physiopathology Parasympatholytics / administration & dosage* Pressure Retrospective Studies Time Factors Urinary Bladder, Neurogenic / drug therapy*, etiology, physiopathology Urodynamics |
| Chemical | |
Reg. No./Substance:
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0/Mandelic Acids; 0/Parasympatholytics; 5633-20-5/oxybutynin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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