| Long-term intermittent compression increases arteriographic collaterals in a rabbit model of femoral artery occlusion. | |
| | |
MedLine Citation:
|
PMID: 17582795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To assess the effects of intermittent limb compression on arterial collateral formation in a rabbit-model. DESIGN: Animal study. MATERIAL AND METHODS: New Zealand rabbits (n=11), aged 2-years, weight of at least 4.0 kg, underwent bilateral superficial femoral artery ligation. In ten of these, the experimental leg underwent 60 minutes of daily intermittent compression for a ten week period with 3 sec/90 mmHg pressure inflation and a cycle of 3 times per minute. The contra-lateral limbs were not treated. At the end of the ten-week period, high-resolution angiograms were obtained by barium infusion into the aorta. The angiograms were analyzed in a blinded manner and the number of collateral arteries larger than 100 microns, was counted. Following perfusion-fixation, histological specimens of transverse sections of the compressed semi-membranous muscle were examined. RESULTS: The compressed limbs demonstrated a significantly (8.1+/-.87 vs 6.0+/-.97; p<0.005) greater number of collateral vessels, ranging in size from 100-700 microns, as compared to the control sides. The mean size of collaterals in the compressed limbs was not significantly different (0.33+/-0.17 vs 0.31+/-0.16). Microscopic examination of the collaterals confirmed remodeling by a typical neo-intima consisting of 6-7 cell-layers. CONCLUSIONS: Intermittent limb compression increases the number of angiographical collateral arteries. |
| | |
Authors:
|
P S van Bemmelen; R G Choudry; M D Salvatore; M Goldenberg; B I Goldman; J Blebea |
Related Documents
:
|
707705 - Femoral artery profundaplasty. 19290575 - Endovascular treatment of a ruptured profunda femoral artery branch after fogarty throm... 18787515 - A noncontact approach for the evaluation of large artery stiffness: a preliminary study. 3034915 - Femoral neuropathy as a complication of aortic surgery. 9560755 - Cerebrovascular emboli related to pulmonary venous thrombosis after lung transplantation. 20305935 - Off-pump correction of coronary fistula: the single suture technique approach. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-19 |
Journal Detail:
|
Title: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery Volume: 34 ISSN: 1078-5884 ISO Abbreviation: Eur J Vasc Endovasc Surg Publication Date: 2007 Sep |
Date Detail:
|
Created Date: 2007-08-10 Completed Date: 2007-10-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9512728 Medline TA: Eur J Vasc Endovasc Surg Country: England |
Other Details:
|
Languages: eng Pagination: 340-6 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA. vanbemp@tuhs.temple.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arterial Occlusive Diseases / physiopathology*, radiography* Barium Sulfate / administration & dosage Collateral Circulation* Contrast Media / administration & dosage Disease Models, Animal Femoral Artery / physiopathology*, radiography*, surgery Intermittent Pneumatic Compression Devices Ligation Muscle, Skeletal / blood supply* Neovascularization, Physiologic* Pressure Rabbits Reproducibility of Results Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 7727-43-7/Barium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ginsenosides promote proliferation of chicken primordial germ cells via PKC-involved activation of N...
Next Document: Regulation of the uterine contractile apparatus and cytoskeleton.