Document Detail

Long-term intermittent compression increases arteriographic collaterals in a rabbit model of femoral artery occlusion.
MedLine Citation:
PMID:  17582795     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the effects of intermittent limb compression on arterial collateral formation in a rabbit-model. DESIGN: Animal study. MATERIAL AND METHODS: New Zealand rabbits (n=11), aged 2-years, weight of at least 4.0 kg, underwent bilateral superficial femoral artery ligation. In ten of these, the experimental leg underwent 60 minutes of daily intermittent compression for a ten week period with 3 sec/90 mmHg pressure inflation and a cycle of 3 times per minute. The contra-lateral limbs were not treated. At the end of the ten-week period, high-resolution angiograms were obtained by barium infusion into the aorta. The angiograms were analyzed in a blinded manner and the number of collateral arteries larger than 100 microns, was counted. Following perfusion-fixation, histological specimens of transverse sections of the compressed semi-membranous muscle were examined. RESULTS: The compressed limbs demonstrated a significantly (8.1+/-.87 vs 6.0+/-.97; p<0.005) greater number of collateral vessels, ranging in size from 100-700 microns, as compared to the control sides. The mean size of collaterals in the compressed limbs was not significantly different (0.33+/-0.17 vs 0.31+/-0.16). Microscopic examination of the collaterals confirmed remodeling by a typical neo-intima consisting of 6-7 cell-layers. CONCLUSIONS: Intermittent limb compression increases the number of angiographical collateral arteries.
P S van Bemmelen; R G Choudry; M D Salvatore; M Goldenberg; B I Goldman; J Blebea
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-19
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  34     ISSN:  1078-5884     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  340-6     Citation Subset:  IM    
Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
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MeSH Terms
Arterial Occlusive Diseases / physiopathology*,  radiography*
Barium Sulfate / administration & dosage
Collateral Circulation*
Contrast Media / administration & dosage
Disease Models, Animal
Femoral Artery / physiopathology*,  radiography*,  surgery
Intermittent Pneumatic Compression Devices
Muscle, Skeletal / blood supply*
Neovascularization, Physiologic*
Reproducibility of Results
Time Factors
Reg. No./Substance:
0/Contrast Media; 7727-43-7/Barium Sulfate

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