Document Detail

Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women.
MedLine Citation:
PMID:  9734729     Owner:  NLM     Status:  MEDLINE    
The long-term clinical effects of soy protein containing various amounts of isoflavones on lipoproteins, mononuclear cell LDL receptor messenger RNA concentrations, and other selected cardiovascular risk factors are not well known. Sixty-six hypercholesterolemic, free-living, postmenopausal women were investigated during a 6-mo parallel-group, double-blind trial with 3 interventions. After a control period of 14 d, all subjects were randomly assigned to 1 of 3 dietary groups (all with 40 g protein): a National Cholesterol Education Program (NCEP) Step 1 diet with protein from casein and nonfat dry milk (control), an NCEP Step 1 diet with protein from isolated soy protein containing moderate amounts of isoflavones (ISP56), or an NCEP Step 1 diet with protein from isolated soy protein containing high amounts of isoflavones (ISP90). Non-HDL cholesterol in both the ISP56 and ISP90 groups was reduced compared with the control group (P < 0.05), whereas total cholesterol was not changed. HDL cholesterol increased in both the ISP56 and ISP90 groups (P < 0.05), whereas the ratio of total to HDL cholesterol decreased significantly in both groups compared with the control (P < 0.05). Mononuclear cell LDL receptor messenger RNA concentrations increased in subjects consuming ISP56 or ISP90 compared with the control (P < 0.05). These results indicate that soy protein, with different amounts of isoflavones, may decrease the risk of cardiovascular disease via improved blood lipid profiles, and that the mechanism by which apolipoprotein B-containing lipoproteins were depressed may be via alterations in LDL receptor quantity or activity.
J A Baum; H Teng; J W Erdman; R M Weigel; B P Klein; V W Persky; S Freels; P Surya; R M Bakhit; E Ramos; N F Shay; S M Potter
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  68     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-09-29     Completed Date:  1998-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  545-51     Citation Subset:  AIM; IM    
Department of Food Science and Human Nutrition, University of Illinois at Urbana/Champaign, USA.
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MeSH Terms
Aged, 80 and over
Body Mass Index
Cardiovascular Diseases / prevention & control
Cholesterol / blood*
Double-Blind Method
Hypercholesterolemia / diet therapy*,  metabolism
Isoflavones / administration & dosage,  pharmacology*
Middle Aged
RNA, Messenger / drug effects,  genetics,  isolation & purification
Receptors, LDL / drug effects*,  metabolism
Soybean Proteins / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Isoflavones; 0/RNA, Messenger; 0/Receptors, LDL; 0/Soybean Proteins; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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