Document Detail

Long-term influence of vasopressin on the control of arterial blood pressure independent of volume changes.
MedLine Citation:
PMID:  6599677     Owner:  NLM     Status:  MEDLINE    
Studies were performed to ascertain the extent to which arterial blood pressure, and fluid and electrolyte changes seen with chronic elevations of plasma vasopressin (AVP) were caused by volume expansion or some other more direct cardiovascular or neural interactions of AVP. Group 1 (n = 7) dogs were infused with AVP (0.36 ng/kg/min) while total body weight and volume were maintained at a constant level by the use of an electronically controlled servocontrol system. Dogs in Group 2 (n = 6) were permitted to drink ad libitum during AVP infusion. Group 3 (n = 6) dogs were maintained with a constant level of H2O intake by intravenous infusion during two weeks AVP administration. The results indicate that chronic elevation of plasma AVP resulted in a prolonged elevation of arterial pressure only when there was a large expansion of total body water. Dogs with total body volume servocontrolled to a constant level (Group 1) and those with a moderate increase in volume (Group 2) exhibited no measureable change in mean arterial pressure during AVP infusion. Dogs with Fixed H2O intake (Group 3) retained a large fluid volume. They exhibited renal escape from AVP and large decreases of plasma osmolality, sodium concentration and plasma renin activity. With as libitum drinking (Group 2), only mild volume expansion occurred which resulted in a partial escape from the volume-retaining effects and smaller decreases of plasma osmolality and sodium. When total body weight and volume were servocontrolled to a constant level, no renal escape occurred and hype-osmolality, hyponatraemia and hyporeninaemia were not observed (Group 1).(ABSTRACT TRUNCATED AT 250 WORDS)
A W Cowley; M M Skelton; D C Merrill
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  2     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1986-06-25     Completed Date:  1986-06-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S337-9     Citation Subset:  IM    
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MeSH Terms
Arginine Vasopressin / blood,  pharmacology*
Blood Pressure / drug effects*
Body Water / drug effects*
Body Weight / drug effects
Drinking / drug effects
Osmolar Concentration
Time Factors
Water-Electrolyte Balance / drug effects
Grant Support
Reg. No./Substance:
113-79-1/Arginine Vasopressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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