Document Detail

Long-term impairment of the lacrimal glands after radioiodine therapy: a cross-sectional study.
MedLine Citation:
PMID:  12397459     Owner:  NLM     Status:  MEDLINE    
Impairment of the lacrimal glands after external radiation has been well documented, but there are only a few reports on the effects of radioiodine therapy on the lacrimal glands. Long-term effects of high-dose radioiodine therapy on tear secretion have not previously been studied. We investigated 175 eyes of 88 patients with a history of radioiodine therapy for thyroid carcinoma (68 females, 20 males; mean age 55+/-16 years, range 17-81 years) and compared them with a sex- and age-matched control group ( n=39). All patients had been given at least 2.96 GBq iodine-131 (maximal administered activity 22.3 GBq (131)I). An ophthalmological investigation was performed 64+/-71 months (range 3-317 months) after initial radioiodine therapy by a single ophthalmologist. Lacrimal gland function was evaluated with three different function tests. External eye morphology was considered, and detailed ophthalmological history-taking was performed. Patients with factors known to affect lacrimal gland function (contact lenses, autoimmune disorders, history of additional radiation exposure) were excluded from the study. A total of 81 patients (92%) had at least one abnormal function test indicating impaired lacrimal gland function. Schirmer's tear test was decreased (<10 mm/5 min) in 47 of the 88 patients and definitely abnormal (<5 mm/5 min) in 35 patients. A tear film break-up time of <10 s was found in 78 patients, and 62 patients had a definitely abnormal break-up time of <5 s. The lacrimal lipid layer was impaired in 43 patients. The function tests were all significantly altered in the study group as compared with the controls ( P<0.005, P<0.001, P<0.001, respectively). Both subjective symptoms of dry eye ( P<0.01) and changes in the external eye morphology ( P<0.001) were significantly more prevalent in the study group. Our findings suggest that in the majority of patients, lacrimal gland function may be permanently impaired after high-dose radioiodine therapy. All three layers of the tear film are involved and there is a pronounced long-term effect on the tear film stability.
Georg Zettinig; Georg Hanselmayer; Barbara J Fueger; Andrea Hofmann; Christian Pirich; Johannes Nepp; Robert Dudczak
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article     Date:  2002-08-28
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  29     ISSN:  1619-7070     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-24     Completed Date:  2003-07-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1428-32     Citation Subset:  IM    
Department of Nuclear Medicine, University of Vienna, Währinger Gürtel 18-20, 1090 Wien, Austria.
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MeSH Terms
Aged, 80 and over
Cohort Studies
Cross-Sectional Studies
Dry Eye Syndromes / diagnosis,  etiology
Follow-Up Studies
Iodine Radioisotopes / administration & dosage,  adverse effects*,  therapeutic use*
Lacrimal Apparatus / injuries,  physiopathology*,  radiation effects*,  secretion
Longitudinal Studies
Middle Aged
Thyroid Neoplasms / radiotherapy*
Reg. No./Substance:
0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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