Document Detail


Long-term impact of diabetes in patients hospitalized with ischemic and non-ischemic heart failure.
MedLine Citation:
PMID:  19878095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Diabetes mellitus (DM) in combination with heart failure (HF) is associated with a high risk of death, but it is uncertain whether the prognosis differs in ischemic and non-ischemic HF groups. DESIGN: One thousand, three hundred and six patients with ischemic HF and 1315 patients with non-ischemic HF were followed for 6.8 years. Risk of all caue mortality was analyzed using Cox proportional hazard models. RESULTS: Mean age was 73 (+/- standard deviation 11) years. Two hundred and forty eight of 1306 (19%) patients with ischemic HF and 172/1315 (13%) patients with non-ischemic HF had DM (p for difference < 0.0001). Overall, 939/1306 (72%) patients in the ischemic HF group, and 835/1315 (64%) patients in the non-ischemic HF group died, respectively. Totally 191/248 (77%) DM patients with ischemic HF, and 127/172 (74%) DM patients with non-ischemic HF died. DM was associated with adjusted hazard ratios (HR) of 1.45 (1.22-1.73, p < 0.0001) if ischemic HF, and 1.50 (1.22-1.84, p < 0.0001) if non-ischemic HF (p for interaction = 0.4), compared to non-DM non-ischemic HF patients. CONCLUSION: The long-term prognosis of DM is equally adverse in ischemic and non-ischemic HF patients.
Authors:
Charlotte Andersson; Peter Weeke; Redi Pecini; Jesper Kjaergaard; Christian Hassager; Lars Køber; Christian Torp-Pedersen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  44     ISSN:  1651-2006     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-09     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  England    
Other Details:
Languages:  eng     Pagination:  37-44     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Gentofte University Hospital, Denmark. ca@heart.dk
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Chi-Square Distribution
Denmark / epidemiology
Diabetes Complications / mortality*,  therapy
Diabetes Mellitus / mortality*
Female
Heart Failure / etiology,  mortality*,  therapy
Hospitalization / statistics & numerical data*
Humans
Inpatients / statistics & numerical data*
Kaplan-Meiers Estimate
Male
Middle Aged
Multicenter Studies as Topic
Myocardial Ischemia / complications,  mortality*,  therapy
Proportional Hazards Models
Randomized Controlled Trials as Topic
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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