| Long-term impact of diabetes in patients hospitalized with ischemic and non-ischemic heart failure. | |
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MedLine Citation:
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PMID: 19878095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Diabetes mellitus (DM) in combination with heart failure (HF) is associated with a high risk of death, but it is uncertain whether the prognosis differs in ischemic and non-ischemic HF groups. DESIGN: One thousand, three hundred and six patients with ischemic HF and 1315 patients with non-ischemic HF were followed for 6.8 years. Risk of all caue mortality was analyzed using Cox proportional hazard models. RESULTS: Mean age was 73 (+/- standard deviation 11) years. Two hundred and forty eight of 1306 (19%) patients with ischemic HF and 172/1315 (13%) patients with non-ischemic HF had DM (p for difference < 0.0001). Overall, 939/1306 (72%) patients in the ischemic HF group, and 835/1315 (64%) patients in the non-ischemic HF group died, respectively. Totally 191/248 (77%) DM patients with ischemic HF, and 127/172 (74%) DM patients with non-ischemic HF died. DM was associated with adjusted hazard ratios (HR) of 1.45 (1.22-1.73, p < 0.0001) if ischemic HF, and 1.50 (1.22-1.84, p < 0.0001) if non-ischemic HF (p for interaction = 0.4), compared to non-DM non-ischemic HF patients. CONCLUSION: The long-term prognosis of DM is equally adverse in ischemic and non-ischemic HF patients. |
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Authors:
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Charlotte Andersson; Peter Weeke; Redi Pecini; Jesper Kjaergaard; Christian Hassager; Lars Køber; Christian Torp-Pedersen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 44 ISSN: 1651-2006 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-09 Completed Date: 2010-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: England |
Other Details:
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Languages: eng Pagination: 37-44 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Gentofte University Hospital, Denmark. ca@heart.dk |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Chi-Square Distribution Denmark / epidemiology Diabetes Complications / mortality*, therapy Diabetes Mellitus / mortality* Female Heart Failure / etiology, mortality*, therapy Hospitalization / statistics & numerical data* Humans Inpatients / statistics & numerical data* Kaplan-Meiers Estimate Male Middle Aged Multicenter Studies as Topic Myocardial Ischemia / complications, mortality*, therapy Proportional Hazards Models Randomized Controlled Trials as Topic Risk Assessment Risk Factors Time Factors Treatment Outcome |
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