| Long-term hydroxyurea therapy in beta-thalassaemia patients. | |
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MedLine Citation:
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PMID: 12605659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The study aimed to investigate the use of hydroxyurea (HU) for the treatment of beta-thalassaemia (beta-thal) patients. METHODS: We examined the haematological effects of orally administered HU (10-20 mg/kg/d) in 11 patients, including four beta-thal major and seven beta-thal intermedia patients. Complete blood count and levels of foetal haemoglobin (HbF), liver enzymes and serum creatinine were evaluated before and during HU. Response to therapy was evaluated at 6 months of treatment. RESULTS: A substantial increase in haemoglobin (Hb) level (4.1 g/dL), leading to complete withdrawal from a regular transfusion programme, was observed in one unique beta-thal major patient. In the beta-thal intermedia patients, increases in Hb level of 1.3, 1.9 and 2.0 g/dL were observed in three of seven (42.9%) patients during HU therapy. The mean values of Hb, mean corpuscular haemoglobin (MCH), and HbF were higher during HU treatment than baseline values (8.7 vs. 7.7 g/dL, P = 0.05; 26.7 vs. 22.9 pg, P = 0.05; 57.2 vs. 44.9%, P = 0.04; respectively). In contrast, the mean reticulocyte count measured during therapy decreased (97.0 x 10(9) vs. 632.0 x 10(9)/L, P = 0.03). No correlations were observed between levels of Hb and HbF (r = 0.77, P = 0.10), and levels of Hb and reticulocyte counts (r = 0.26, P = 0.31). No significant toxicity was observed in our patients. CONCLUSION: These results suggest that HU may improve Hb levels in beta-thal. Thus, we may conclude that a large trial concerning the response to HU in these patients should be carried out to clarify this issue. |
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Authors:
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Erich Vinicius de Paula; Carmen Silvia Passos Lima; Valder Roberval Arruda; Fernando Lopes Alberto; Sara Teresinha Ollala Saad; Fernando Ferreira Costa |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: European journal of haematology Volume: 70 ISSN: 0902-4441 ISO Abbreviation: Eur. J. Haematol. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-02-27 Completed Date: 2003-05-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: Denmark |
Other Details:
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Languages: eng Pagination: 151-5 Citation Subset: IM |
Affiliation:
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Haematology and Haemotherapy Centre, and Department of Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blood Cell Count Clinical Enzyme Tests Creatine / blood Erythrocyte Indices / drug effects Fetal Hemoglobin / drug effects Hemoglobins / drug effects Humans Hydroxyurea / administration & dosage, therapeutic use*, toxicity Liver / enzymology Male Reticulocyte Count beta-Thalassemia / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 127-07-1/Hydroxyurea; 57-00-1/Creatine; 9034-63-3/Fetal Hemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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