Document Detail

Long-term histopathologic evaluation of inferior vena cava after modified Greenfield filter implantation. Experimental study in sheep.
MedLine Citation:
PMID:  15507896     Owner:  NLM     Status:  MEDLINE    
AIM: The authors assess a modified Greenfield filter (GF) for the long-term patency, filter tilting and histopathologic alterations of the inferior vena cava (IVC). METHODS: Adult sheep (n=7) underwent modified GF placement in the IVC. Cavograms were obtained every 3 months and pulmonary angiography at 12 months. Histopathologic and scanning electron microscopy (SEM) analyses were performed on the IVC explanted at 12 months. RESULTS: Cavograms showed that all IVC were patent at the end of the study. Filter tilting occurred in 2/7 animals and extrusion of struts was not observed. Macroscopic examination at explantation showed minimal venous wall thickening. Microscopic examination showed minimal IVC fibrosis and intimal hyperplasia. SEM showed endothelium on the IVC surface at the filter implantation site and a presumed endothelial layer covering partially or totally the struts. The interface filter-IVC was covered by deposits of leucocytes and platelets. No signs of pulmonary embolism were found in all pulmonary angiograms of both groups. CONCLUSION: The modified filter presented good biocompatibility, stability and absence of thrombogenicity at 12 months. It presented low tendency to tilting and extrusion of struts. The long-term histopathologic alterations in vena caval wall were minimal and the appearance of the studied filters in the IVC was similar to stents placed in the arterial system.
W B Yoshida; J Sequera; F H De Abreu Maffei
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  23     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-10-27     Completed Date:  2005-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  170-6     Citation Subset:  IM    
Department of Surgery and Orthopedics, Botucatu School of Medicine, Botucatu, São Paulo, Brazil.
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MeSH Terms
Biocompatible Materials
Microscopy, Electron, Scanning
Prosthesis Design
Vascular Patency
Vena Cava Filters*
Vena Cava, Inferior / pathology*
Reg. No./Substance:
0/Biocompatible Materials

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