Document Detail

Long-term high-colloid oncotic therapy for ischemic brain edema in gerbils.
MedLine Citation:
PMID:  7482664     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: We evaluated the effects of long-term administration of high-colloid oncotic pressure on ischemic brain edema in Mongolian gerbils. METHODS: Animals that exhibited stroke after 35 minutes of unilateral forebrain ischemia were used. The gerbils were divided into albumin- (1 g/kg body wt, 25% albumin; n = 30) and saline-injected (4 mL/kg; n = 30) groups. Both agents were administered intravenously every 12 hours starting immediately after the recirculation. Plasma colloid oncotic pressure, serum sodium and potassium concentrations, and brain water, sodium, and potassium content were measured 24, 48, and 72 hours after recirculation. RESULTS: Plasma colloid oncotic pressure at 24, 48, and 72 hours after recirculation was significantly higher in the albumin- (26.1 +/- 2.3 mm Hg) than in the saline-treated group (18.5 +/- 1.9 mm Hg; P < .01), and brain water content of the ischemic hemisphere was significantly lower in the albumin group (79.5%, 80.2%, and 80.5%, respectively) than in the saline group (80.9%, 81.6%, and 82.1%, respectively; P < .05) at all three time points. Brain sodium content at 24 hours was significantly lower in the albumin than in the saline group (P < .05), while brain potassium content at 24 and 48 hours was significantly higher in the albumin than in the saline group (P < .05). The changes in brain water and sodium plus potassium content, which were calculated from differences between the ischemic and nonischemic hemispheres, showed a significant correlation in both groups (P < .01), but there was no significant difference between the linear regression lines for both groups. CONCLUSIONS: Long-term high-colloid oncotic pressure was effective in treating ischemic brain edema, probably acting by diminishing the bulk flow through the disrupted blood-brain barrier and ameliorating the vasogenic edema.
Y Hakamata; U Ito; S Hanyu; M Yoshida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  26     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-12-07     Completed Date:  1995-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2149-53     Citation Subset:  IM    
Laboratory of Experimental Medicine, Jichi Medical School, Tochigi-ken, Japan.
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MeSH Terms
Albumins / administration & dosage*,  therapeutic use
Brain Edema / etiology,  metabolism,  therapy*
Brain Ischemia / complications,  metabolism,  therapy*
Hydrostatic Pressure
Injections, Intravenous
Potassium / analysis
Sodium / analysis
Water / analysis
Reg. No./Substance:
0/Albumins; 0/Colloids; 7440-09-7/Potassium; 7440-23-5/Sodium; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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