Document Detail

Long-term health experience of jet engine manufacturing workers: v. Issues with the analysis of non-malignant central nervous system neoplasms.
MedLine Citation:
PMID:  22223053     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: We attempted to examine non-malignant central nervous system (CNS) neoplasms incidence rates for workers at 8 jet engine manufacturing facilities in Connecticut. The objective of this manuscript is to describe difficulties encountered regarding these analyses to aid future studies.
METHODS: We traced the cohort for incident cases of CNS neoplasms in states where 95% of deaths in the total cohort occurred. We used external and internal analyses in an attempt to obtain the true risk of non-malignant CNS in the cohort. Because these analyses were limited by data constraints, we conducted sensitivity analyses, including using state driver's license data to adjust person-year stop dates to help minimize underascertainment and more accurately determine cohort risk estimates.
RESULTS: We identified 3 unanticipated challenges: case identification, determination of population-based cancer incidence rates, and handling of case underascertainment. These factors precluded an accurate assessment of non-malignant CNS neoplasm incidence risks in this occupational epidemiology study.
CONCLUSIONS: The relatively recent (2004) mandate of capturing non-malignant CNS tumor data at the state level means that, in time, it may be possible to conduct external analyses of these data. Meanwhile, similar occupational epidemiology studies may be limited to descriptive analysis of the non-malignant CNS case characteristics.
Jeanine M Buchanich; Ada O Youk; Gary M Marsh; Kathleen J Kennedy; Steven E Lacey; Roger P Hancock; Nurtan A Esmen; Michael A Cunningham; Frank S Leiberman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of registry management     Volume:  38     ISSN:  1945-6123     ISO Abbreviation:  J Registry Manag     Publication Date:  2011  
Date Detail:
Created Date:  2012-01-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804163     Medline TA:  J Registry Manag     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-9     Citation Subset:  IM    
Center for Occupational Biostatistics and Epidemiology, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
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