Document Detail


Long-term habituation to repeated loud noise is impaired by relatively short interstressor intervals in rats.
MedLine Citation:
PMID:  18298264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The phenomenon of spaced (longer intertrial interval) compared with massed (shorter intertrial interval) training leading to better long-term habituation and associative learning is well documented. However, the effects of intertrial intervals on response habituation to repeated stress exposures have not been previously examined. The present experiments found that massed (six 30-min exposures of 95 dB white noise in 6 hr) and spaced (one 30-min exposure daily for 6 days) noise exposures led to similar habituation of plasma corticosterone and ACTH responses, heart rate, and core body temperature after the 6th exposure in male Sprague-Dawley rats. However, these habituated responses were not retained in the massed group on a similar noise re-exposure 48 hr later, compared with the spaced group. The habituated responses found in the massed group after the 6 noise exposures were not due to differential hearing threshold shifts, as examined with modifications of the acoustic startle reflex. These data indicate that relatively short interstressor intervals impair long-term stress adaptation. This series of studies supports the idea of distinct short- and long-term habituation processes to stress responsiveness.
Authors:
Cher V Masini; Heidi E W Day; Serge Campeau
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  122     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-26     Completed Date:  2008-06-23     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-23     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 APA, all rights reserved.
Affiliation:
Department of Psychology, University of Colorado, Boulder 80309-0345, USA. masinic@colorado.edu
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation / methods
Adrenocorticotropic Hormone / blood
Analysis of Variance
Animals
Behavior, Animal
Body Temperature / physiology
Corticosterone / blood
Dose-Response Relationship, Radiation
Habituation, Psychophysiologic / physiology*
Heart Rate / physiology
Male
Noise / adverse effects*
Rats
Rats, Sprague-Dawley
Startle Reaction / physiology*
Stress, Psychological / blood,  physiopathology*
Time Factors
Grant Support
ID/Acronym/Agency:
K02 MH068016-04/MH/NIMH NIH HHS; R01 MH065327/MH/NIMH NIH HHS; R01 MH065327-05/MH/NIMH NIH HHS; R01 MH077152-04/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
50-22-6/Corticosterone; 9002-60-2/Adrenocorticotropic Hormone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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