Document Detail

Long-term function and manovolumetric characteristics after ileal pouch-anal anastomosis for ulcerative colitis.
MedLine Citation:
PMID:  17225209     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Long-term pouch function and physiological characteristics after ileal pouch-anal anastomosis (IPAA) are poorly described. The aim of this study was to undertake a prospective investigation of long-term pouch function and manovolumetric characteristics. METHODS: Forty-two patients with a median follow-up of 16 years after IPAA were included. Function was assessed using a questionnaire and a score was calculated ranging from 0 to 15 (15 being the worst). Manovolumetry was performed and pouchitis recorded. A paired analysis was conducted, as the results were compared with previous data for each patient. RESULTS: The median functional score was 3.5 (range 0-10) at 2 years and 5 (range 1-11) at 16 years (P = 0.013). Resting anal canal pressures were higher (P < 0.001) and squeeze pressures lower (P = 0.008) at long-term follow-up. Ileal pouch volumes at distension pressures of 10, 20 and 40 cm H(2)O were diminished at 16 years (P < 0.001, P = 0.005 and P = 0.058 respectively). The volume and pressure for first sensation and urge to defaecate were reduced. Increased age correlated positively with a poor functional score. A history of pouchitis did not affect functional or physiological characteristics. CONCLUSION: Ileal pouch function declines in the long term. The reasons are unclear, but the ageing process may have an impact.
J Bengtsson; L Börjesson; U Lundstam; T Oresland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  94     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-28     Completed Date:  2007-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  327-32     Citation Subset:  AIM; IM    
Copyright Information:
(c) 2007 British Journal of Surgery Society Ltd.
Department of Surgery, Sahlgrenska University Hospital/Ostra, SE-416 85 Göteborg, Sweden.
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MeSH Terms
Age Factors
Anal Canal / physiopathology*,  surgery
Anastomosis, Surgical
Colitis, Ulcerative / surgery*
Colonic Pouches / physiology*
Follow-Up Studies
Ileum / surgery*
Middle Aged
Proctocolectomy, Restorative* / adverse effects
Prospective Studies
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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