Document Detail

Long-term follow-up of thyroid function in patients who received bone marrow transplantation during childhood and adolescence.
MedLine Citation:
PMID:  15579747     Owner:  NLM     Status:  MEDLINE    
An increasing number of long-term surviving bone marrow transplant (BMT) recipients have recovered from their primary disease but are at risk of developing failure of endocrine organs. We investigated 147 patients who underwent allogeneic BMT. Thyroid function was evaluated by serial measurement of basal TSH and free T4 levels as well as by TRH provocative test. Thyroid ultrasound examination was performed for evaluation of thyroid tumor after BMT. Five patients were found to have overt thyroid dysfunction (hypothyroidism in four patients and hyperthyroidism in one patient). Twenty-three patients in the under 9-yr-old group at BMT and 16 patients in the over 10-yr-old group at BMT had subclinical compensated hypothyroidism. Younger age at BMT was the strongest factor for developing thyroid dysfunction, compared with older age (P < 0.001). Only in patients with subclinical compensated hypothyroidism did median basal and peak TSH increase to the upper half of the normal range by 8 yr after BMT and then returned slightly to the middle of the normal range spontaneously. These results suggest that thyroid dysfunction in long-term BMT survivors depends on age at BMT, with a greater risk among younger patients, indicating the need for life-long surveillance.
Hiroyuki Ishiguro; Yukiharu Yasuda; Yuuichiro Tomita; Tsuyoshi Shinagawa; Takashi Shimizu; Tsuyoshi Morimoto; Kinya Hattori; Masae Matsumoto; Hiroyasu Inoue; Hiromasa Yabe; Miharu Yabe; Osamu Shinohara; Shunichi Kato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  89     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-06     Completed Date:  2005-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5981-6     Citation Subset:  AIM; IM    
Department of Pediatrics, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
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MeSH Terms
Adenoma / etiology
Bone Marrow Transplantation / adverse effects*
Follow-Up Studies
Hyperthyroidism / etiology
Hypothyroidism / etiology
Thyroid Diseases / epidemiology,  etiology*,  physiopathology*,  ultrasonography
Thyroid Function Tests
Thyroid Gland / physiopathology*,  ultrasonography
Thyroid Neoplasms / etiology

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