Document Detail


Long-term follow-up of recipients of allogeneic bone marrow grafts reveals no progressive telomere shortening and provides no evidence for haematopoietic stem cell exhaustion.
MedLine Citation:
PMID:  11841457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Accelerated telomere shortening has been proposed as a possible long-term risk of allogeneic bone marrow transplantation (allo-BMT). In this study we monitored telomere length in white blood cells (WBC), granulocytes, and naïve and memory CD4+ T lymphocytes in recipients of allo-BMT at long-term follow-up. Peripheral blood was collected from 10 allo-BMT recipients and donors at a median interval of 18 years after allo-BMT. Telomere length was determined using Southern blot analysis. Similar to results previously reported at short-term follow-up, a small difference in telomere length (0.1-0.3 kb) between recipients and donors was detected in WBC, granulocytes and naïve CD4+ T cells. Our data therefore provide no evidence for sustained telomere shortening in leucocytes, and render the possibility of long-term haematopoietic graft failure unlikely. In addition, we observed two phenomena that may be related to involution of the thymus. First, the number of naïve CD4+ T cells in the blood was significantly lower in recipients (0.4 x 10(9)/l) than in donors (0.7 x 10(9)/l) (P < 0.05). Second, telomeres in memory CD4+ T cells from recipients were on average 0.6 kb shorter than those from donors (P = 0.01). The latter may be related to the reported rapid peripheral expansion of memory T cells immediately after transplantation.
Authors:
Elmar S D de Pauw; Sigrid A Otto; Juul T Wijnen; Jaak M Vossen; Margreet H van Weel; Hans J Tanke; Frank Miedema; Roel Willemze; Helene Roelofs; Willem E Fibbe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  116     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-13     Completed Date:  2002-03-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  491-6     Citation Subset:  IM    
Affiliation:
Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Anemia, Aplastic / immunology,  therapy
CD4-Positive T-Lymphocytes / ultrastructure
Child
Child, Preschool
Follow-Up Studies
Granulocytes / ultrastructure
Hematopoietic Stem Cell Transplantation*
Humans
Immunologic Memory
Leukemia / genetics,  immunology,  therapy*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / immunology,  therapy
Leukemia, Myeloid / immunology,  therapy
Leukocytes / ultrastructure*
Lymphocyte Count
Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology,  therapy
Telomere / ultrastructure*
Tissue Donors
Transplantation, Homologous

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