Document Detail

Long term follow up of premature infants: detection of strabismus, amblyopia, and refractive errors.
MedLine Citation:
PMID:  10966945     Owner:  NLM     Status:  MEDLINE    
AIM: To establish recommendations for long term ophthalmological follow up of prematurely born infants. METHODS: 130 infants with a gestational age (GA) <37 weeks and born between 1 November 1989 and 31 October 1990 were enrolled in a prospective study about the development of strabismus, amblyopia, and refractive errors. Infants were subdivided in three groups according to GA: A <28 weeks (n=32), B >/=28-</=32 weeks (n=64), C >32-<37 weeks (n=34). Ophthalmological assessment took place at the postconceptional age of 32 weeks, at term and at 3, 6, 12, and 30 months post term. At the age of 5 years parents received a questionnaire and a majority of the children was examined again (n=99). RESULTS: At the age of 5 years 46 infants were known to have strabismus (n=29) and/or amblyopia (n=22) and/or refractive errors (n=22). Statistical analysis showed that gestational age, duration of supplementary oxygen, and duration of hospitalisation were important predictive variables for the development of strabismus, amblyopia, or refractive errors (SAR) at the age of 5 years (p<0.05). Infants with a GA </=32 weeks had a significantly higher risk of developing SAR than infants with a GA >32 weeks, who developed an incidence comparable with the normal population. Strabismus developed mainly in the first year of life and at the age of 5 years. Most infants with amblyopia were detected at the age of 2-3 years. Refractive errors were found in the first year of life and at the age of 2.5 and 5 years. CONCLUSION: Infants with a GA <32 weeks should be selected for long term ophthalmological follow up. These infants should be screened at the age of 1 year, in the third year of life (preferably at 30 months), and just before school age (including testing of visual acuity with optotypes).
N E Schalij-Delfos; M E de Graaf; W F Treffers; J Engel; B P Cats
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  84     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-10     Completed Date:  2000-10-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  963-7     Citation Subset:  IM    
FC Donders Institute of Ophthalmology, University Hospital, Utrecht, Netherlands.
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MeSH Terms
Amblyopia / diagnosis*,  epidemiology
Analysis of Variance
Follow-Up Studies
Gestational Age
Infant, Newborn
Infant, Premature*
Logistic Models
Netherlands / epidemiology
Prospective Studies
Refractive Errors / diagnosis*,  epidemiology
Strabismus / diagnosis*,  epidemiology
Time Factors

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