Document Detail

Long term follow up of patients with IgA nephropathy.
MedLine Citation:
PMID:  8164897     Owner:  NLM     Status:  MEDLINE    
AIM: To assess the long term outcome of patients with IgA nephropathy. METHOD: The outcome of 151 patients (120 male; mean age 32.5, median age 29.6, SD 15.4 years; 146 Caucasian) with biopsy-proven IgA nephropathy. The patients were enrolled between 30 April 1973 and 21 August 1992. RESULTS: Ninety-five (63%) of the patients presented with microscopic haematuria, with or without proteinuria and/or renal insufficiency. At presentation renal insufficiency was present in 34% and hypertension in 48% of patients. During a mean follow up period of 63.3 months (range 0-233 months) 12 patients have reached end stage renal failure, five have died of a nonrenal cause and 25 were lost to follow up. The actuarial renal survival rate was 92.6% at five years and 91.1% at both 10 and 15 years. A significantly poorer renal survival rate was seen in those patients with a plasma creatinine > or = 0.12 mmol/L, hypertension, a serum albumin of < 35 g/L, or a 24 hour urinary albumin excretion > or = 1.0 g at presentation, and this became apparent within the first few years of follow up. CONCLUSIONS: The long term outcome of IgA nephropathy is better than previously reported. Those patients with a poor prognosis can be identified with considerable certainty at presentation.
R R Bailey; K L Lynn; R A Robson; A H Smith; J E Wells
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New Zealand medical journal     Volume:  107     ISSN:  0028-8446     ISO Abbreviation:  N. Z. Med. J.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-20     Completed Date:  1994-05-20     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0401067     Medline TA:  N Z Med J     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  142-4     Citation Subset:  IM    
Department of Nephrology, Christchurch Hospital.
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MeSH Terms
Actuarial Analysis
Age Distribution
Age Factors
European Continental Ancestry Group
Follow-Up Studies
Glomerulonephritis, IGA / complications,  ethnology,  mortality*
Hematuria / etiology
Hypertension, Renal / etiology
Middle Aged
New Zealand / epidemiology
Oceanic Ancestry Group
Proteinuria / etiology
Sex Distribution
Survival Analysis
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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