Document Detail

Long-term follow-up of patients with acute liver failure of indeterminate aetiology.
MedLine Citation:
PMID:  19086167     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the clinical characteristics of patients with acute liver failure of indeterminate cause and their long-term outcome in comparison with patients with acute liver failure of obvious aetiology (acetaminophen and mushroom poisoning, Budd-Chiari syndrome, acute viral hepatitis) and other controls (idiosyncratic drug reactions, autoimmune hepatitis and Wilson's disease). MATERIAL AND METHODS: All patients with acute liver failure and listed for liver transplantation in Sweden between 1984 and 2006 were included in a retrospective analysis. RESULTS: A total of 71 patients with acute liver failure were identified, 33 with indeterminate cause (IDC group), 23 with obvious aetiology (OE group) and 15 other controls (OC group). Before admission to the transplant centre, IDC patients were hospitalized in the referring hospital for 9 days (4-15) versus 1.5 days (1-3) in the OE group (p<0.001) and 7 days (2-14) in the OC group (NS). Serum bilirubin was higher (p<0.001), whereas peak creatinine was lower (p=0.001) in the IDC group compared with the OE group but was not significantly different from the OC group. There were no significant differences in 1-, 3-, 5- and 10-year patient and graft survival rates between the IDC group and the OE or the OC group. CONCLUSIONS: Patients with acute liver failure of indeterminate cause seem to differ from those with obvious aetiology in clinical and biochemical presentation but are similar to other controls. The overall long-term outcome seems to be similar in patients with an unknown aetiology as in those with a specific aetiology.
Gu Wei; Evangelos Kalaitzakis; Annika Bergquist; Einar Björnsson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  43     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-12-15     Completed Date:  2009-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  984-91     Citation Subset:  IM    
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
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MeSH Terms
Acetaminophen / adverse effects*
Analgesics, Non-Narcotic / adverse effects
Budd-Chiari Syndrome / complications*
Disease Progression
Follow-Up Studies
Hepatitis, Viral, Human / complications*
Liver Failure, Acute / diagnosis,  etiology*,  surgery
Liver Transplantation*
Middle Aged
Mushroom Poisoning / complications*
Retrospective Studies
Risk Factors
Time Factors
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen

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