| Long-term follow-up of neoadjuvant chemotherapy with 5-fluorouracil and cisplatin with surgical resection and possible postoperative radiotherapy and/or chemotherapy in squamous cell carcinoma of the esophagus. | |
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MedLine Citation:
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PMID: 8462027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seventy patients with local squamous cell carcinoma of the esophagus were treated between 1981 and 1990 with preoperative chemotherapy, surgical resection, and possible postoperative radiation therapy and/or chemotherapy. Chemotherapy included two cycles of 5-fluorouracil (1000 mg/m2) by continuous intravenous infusion on days 1-4 and cisplatin (100 mg/m2) on day 4. Complete clinical response (CCR) was achieved in 28 (41%) patients, partial clinical response (PCR) in 17 (25%), and no response in 23 (34%). Fifty-five (81%) patients were resected, 6 (9%) were explored, and 7 (10%) were unable to have surgery. Microscopic analysis of 55 resected patients showed 50 (91%) with active tumor, 1 (2%) with necrotic tumor, and 4 (7%) with a pathological complete response to chemotherapy. Twenty-six of the 55 resected patients (47%) had no gross evidence of disease at the time of surgical inspection. Median overall survival was 21.86 months (range 2-107 months) for all patients and 26.71 months (range 2-107 months) for resected patients. Actuarial 5-year survival rate was 31% for all patients and 39% for resected patients. Prolonged survival correlates with complete clinical response to chemotherapy, low pathological stage of disease, and successful resection of the lesion. |
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Authors:
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R W Carey; A D Hilgenberg; E W Wilkins; N C Choi; D J Mathisen; H C Grillo; J C Wain; D L Logan; C Bromberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer investigation Volume: 11 ISSN: 0735-7907 ISO Abbreviation: Cancer Invest. Publication Date: 1993 |
Date Detail:
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Created Date: 1993-05-04 Completed Date: 1993-05-04 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 8307154 Medline TA: Cancer Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 99-105 Citation Subset: IM |
Affiliation:
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Department of Medical Service, Massachusetts General Hospital, Harvard Medical School, Boston 02114. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Carcinoma, Squamous Cell / drug therapy*, mortality, pathology, radiotherapy, surgery Chemotherapy, Adjuvant Cisplatin / administration & dosage, adverse effects Combined Modality Therapy Drug Administration Schedule Esophageal Neoplasms / drug therapy*, mortality, pathology, radiotherapy, surgery Female Fluorouracil / administration & dosage, adverse effects Follow-Up Studies Humans Infusions, Intravenous Male Middle Aged Neoplasm Invasiveness Survival Rate |
| Chemical | |
Reg. No./Substance:
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15663-27-1/Cisplatin; 51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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