| Long-term follow-up data may help manage patient and parent expectations for pediatric patients undergoing thyroidectomy. | |
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MedLine Citation:
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PMID: 23158186 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: We investigated the incidence and impact of postoperative complications in children who underwent total thyroidectomy (TTx). METHODS: The records of all pediatric patients undergoing TTx (2001-2011) at our institution were retrospectively reviewed for the occurrence of biochemical hypothyroidism (thyroid-stimulating hormone >10 mIU/mL), laboratory assessments, and medication nonadherence. RESULTS: The 74 patients (median age, 12.5 years) had thyroid cancer (differentiated, n = 39; medullary, n = 16) or benign pathology (n = 19; 16 with multiple endocrine neoplasia type 2A). The median postoperative follow-up was 3.2 years; 46 patients (62%) had ≥1 year follow-up. Forty-one percent had ≥1 period of medication nonadherence; this was not associated with age at TTx (P = .30). Non-treatment-related hypothyroidism occurred in 33% of patients during postoperative year (POY) 1. The number of POY1 laboratory assessments among the 30% of patients with parathyroid dysfunction was more than twice that among patients with normal parathyroid function (median assessments per year 8 vs 3; P < .0001). Forty-four percent of patients/families reported behavioral or physiologic changes; 40% were concomitant with abnormal thyroid function. CONCLUSION: More than 40% of pediatric patients were unable to fully adhere to postoperative medication regimens, and non-treatment-related hypothyroidism was common. Postoperative hypoparathyroidism doubled the number of laboratory assessments obtained. These data may help families better prepare for TTx sequelae. |
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Authors:
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Lilah F Morris; Steven G Waguespack; Carla L Warneke; Haengrang Ryu; Anita K Ying; Barbara J Anderson; Erich M Sturgis; Gary L Clayman; Jeffrey E Lee; Douglas B Evans; Elizabeth G Grubbs; Nancy D Perrier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery Volume: 152 ISSN: 1532-7361 ISO Abbreviation: Surgery Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: United States |
Other Details:
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Languages: eng Pagination: 1165-71 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2012 Mosby, Inc. All rights reserved. |
Affiliation:
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Section of Surgical Endocrinology, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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