Document Detail


Long-term follow-up data may help manage patient and parent expectations for pediatric patients undergoing thyroidectomy.
MedLine Citation:
PMID:  23158186     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: We investigated the incidence and impact of postoperative complications in children who underwent total thyroidectomy (TTx).
METHODS: The records of all pediatric patients undergoing TTx (2001-2011) at our institution were retrospectively reviewed for the occurrence of biochemical hypothyroidism (thyroid-stimulating hormone >10 mIU/mL), laboratory assessments, and medication nonadherence.
RESULTS: The 74 patients (median age, 12.5 years) had thyroid cancer (differentiated, n = 39; medullary, n = 16) or benign pathology (n = 19; 16 with multiple endocrine neoplasia type 2A). The median postoperative follow-up was 3.2 years; 46 patients (62%) had ≥1 year follow-up. Forty-one percent had ≥1 period of medication nonadherence; this was not associated with age at TTx (P = .30). Non-treatment-related hypothyroidism occurred in 33% of patients during postoperative year (POY) 1. The number of POY1 laboratory assessments among the 30% of patients with parathyroid dysfunction was more than twice that among patients with normal parathyroid function (median assessments per year 8 vs 3; P < .0001). Forty-four percent of patients/families reported behavioral or physiologic changes; 40% were concomitant with abnormal thyroid function.
CONCLUSION: More than 40% of pediatric patients were unable to fully adhere to postoperative medication regimens, and non-treatment-related hypothyroidism was common. Postoperative hypoparathyroidism doubled the number of laboratory assessments obtained. These data may help families better prepare for TTx sequelae.
Authors:
Lilah F Morris; Steven G Waguespack; Carla L Warneke; Haengrang Ryu; Anita K Ying; Barbara J Anderson; Erich M Sturgis; Gary L Clayman; Jeffrey E Lee; Douglas B Evans; Elizabeth G Grubbs; Nancy D Perrier
Related Documents :
24469876 - Early left ventricular functional alterations in patients with obstructive sleep apnea ...
23986646 - Impact and indication of early systemic corticosteroids for very severe community-acqui...
20522566 - The risk of acute radiocontrast-mediated kidney injury following endovascular therapy f...
25113666 - The palmar approach for pip-arthroplasty according to simmen: results after 8 years fo...
20831776 - The belgian mira (mabthera in rheumatoid arthritis) registry: clues for the optimizatio...
22325936 - Primary angioplasty in northern galicia: care changes and results following implementat...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery     Volume:  152     ISSN:  1532-7361     ISO Abbreviation:  Surgery     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1165-71     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Section of Surgical Endocrinology, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Resection of adrenocortical carcinoma is less complete and local recurrence occurs sooner and more o...
Next Document:  Should patients with Cowden syndrome undergo prophylactic thyroidectomy?