| Long-term follow-up of co-administration of diltiazem and cyclosporine in Chinese kidney transplant recipients. | |
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MedLine Citation:
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PMID: 20370446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Co-administration of diltiazem and cyclosporine A (CsA) in kidney transplant recipients shows improvement of renal transplantation outcomes. METHODS: We respectively analyzed 1531 kidney transplant recipients treated by different immunosuppressive therapy schemes from 1986 to 2003. They were divided into three groups depending on their immunosuppressive therapy schemes: control group with a standard triple therapy without use of diltiazem; study group I with the combination of diltiazem and the standard triple therapy but slightly low CsA; study group II with combination of diltiazem and a modified standard triple therapy but lower CsA. The CsA blood concentrations, posttransplant complications, and long-term survival in the three groups were compared. RESULTS: The results showed that the patient and allograft survival in the study group II was 69.9 and 65.1%, respectively, significantly higher than that in the control group (50.7 and 47.6%). Occurrence of hepatotoxicity and nephrotoxicity episodes was higher in the control group than those in the study group I and the study group II. The incidence of acute rejection in the control group was 30.3% (23/76), similar to 28.0% (184/657) in study group I, but statistically significantly higher than 7.6% (61/798) in the study group II. CONCLUSION: Combination of diltiazem and CsA in the kidney allograft recipients tends to reduce the CsA oral dosage, improve patient survival, and decrease the occurrence of hepatotoxicity and nephrotoxicity. |
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Authors:
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Wujun Xue; Xiaoming Ding; Puxun Tian; Xiaoming Pan; Hang Yan; Jun Hou; Xinshun Feng; Heli Xiang; Xiaohui Tian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Renal failure Volume: 32 ISSN: 1525-6049 ISO Abbreviation: Ren Fail Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-07-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: England |
Other Details:
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Languages: eng Pagination: 314-9 Citation Subset: IM |
Affiliation:
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Kidney Transplantation Center, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China. xw5886@pub.xaonline.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Calcium Channel Blockers / administration & dosage* Cyclosporine / administration & dosage*, adverse effects, pharmacokinetics Diltiazem / administration & dosage* Drug Therapy, Combination Female Graft Survival Humans Immunosuppressive Agents / administration & dosage*, adverse effects, pharmacokinetics Kidney Transplantation / mortality Male Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Immunosuppressive Agents; 42399-41-7/Diltiazem; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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