Document Detail


Long-term follow up of the Biocor porcine bioprosthesis in the mitral position.
MedLine Citation:
PMID:  17152783     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIM OF THE STUDY: The study aim was to review the long-term results of mitral valve replacement (MVR) with the Biocor porcine bioprosthesis, in order to investigate patient survival and valve-related complications. METHODS: Data were presented for 546 patients (320 females, 226 males; mean age 49.2 +/- 17.1 years) who underwent MVR with the Biocor porcine bioprosthesis between March 1983 and December 2000. Preoperatively, rheumatic fever was present in 42.3% of patients. Associated procedures were performed in 179 patients (32.7%), and myocardial revascularization in 54 (9.9%). Preoperatively, 41.9% of patients were in NYHA class IV. Postoperative follow up was conducted by telephone interviews, questionnaires, or examination of hospital records. RESULTS: The hospital mortality was 9.5% (n=52); of these patients, 30 died after their first MVR and 22 after mitral reoperation. Mortality after isolated MVR was 7.6%. The total follow up was 2,148.9 patient-years, and actuarial survival was 45.0 +/- 15.8% at 15 years. Freedom from structural valve deterioration (SVD) was 51.8 +/- 13.8% for patients aged <50 years, 88.7 +/- 5.1% for those aged 51-60 years, and 84.0 +/- 9.8% for those aged 61-80 years. The incidence of prosthetic valve endocarditis was low, with 88.8 +/- 6.1% non-recurrence in 15 years. Freedom from reoperation was 33.9 +/- 10.4%, and from thromboembolism was 82.3 +/- 15.0%. Freedom from valve-related mortality was 80.7 +/- 12.5% during a 15-year period. CONCLUSION: The 15-year clinical results with the Biocor porcine bioprosthesis in the mitral position were excellent in a young, predominantly rheumatic, patient population which, preoperatively, was in a grave clinical condition. The incidence of valve-related complications was low, as was that of SVD in patients aged >50 years.
Authors:
Pablo M A Pomerantzeff; Carlos M A Brandão; João M A C Albuquerque; Noedir A G Stolf; Max Grinberg; Sérgio A Oliveira
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  15     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-12-08     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  763-6; discussion 766-7     Citation Subset:  IM    
Affiliation:
Heart Institute (InCor), University of Sao Paulo Medical School, São Paulo, Brazil. dcipablo@incor.usp.br
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bioprosthesis / statistics & numerical data
Brazil / epidemiology
Child
Child, Preschool
Comorbidity
Disease-Free Survival
Equipment Failure Analysis
Female
Heart Valve Prosthesis / statistics & numerical data*
Hospital Mortality
Humans
Incidence
Longitudinal Studies
Male
Mitral Valve Insufficiency / mortality*,  surgery*
Prosthesis Failure
Prosthesis-Related Infections / mortality*
Risk Assessment / methods*
Risk Factors
Survival Analysis
Survival Rate
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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