Document Detail

Long-term feeding of corn oil, beef tallow, or menhaden oil and eicosanoid levels in BHE/cdb rats.
MedLine Citation:
PMID:  1336688     Owner:  NLM     Status:  MEDLINE    
The effects of long-term feeding of 2 or 10% fat diets containing corn oil, beef tallow, or menhaden oil on the levels of eicosanoids in brain, plasma, and kidney medulla were studied. Male BHE/cdb rats, which carry a genetic trait for non-insulin-dependent diabetes mellitus, were fed these diets for 9 mo, at which time their glucose tolerance levels were determined, as were brain, kidney medulla, and plasma levels of PGE2, 6-keto-PGF1 alpha, and LTB4. Glucose tolerance was abnormal in the 2 and 10% corn oil groups and normal in the 10% menhaden oil groups. The glucose tolerance levels of the other groups were only slightly disturbed. The levels of LTB4 in kidney and plasma were not affected by dietary fat type or amount. LTB4 levels were significantly higher in the brains of rats fed a low level of beef tallow than in the brains of rats fed a higher level of beef tallow or a low level of menhaden or corn oil. LTB4 values for the brains of rats fed the other diets were intermediate and not different from the aforementioned values. The levels of 6-keto-PGF1 alpha were highest in rats fed the 10% corn oil diet regardless of the tissue assayed. Rats fed the 2 or 10% beef tallow or menhaden oil were not different but had lower levels of this eicosanoid metabolite than rats fed the corn oil diet. PGE2 levels followed the same pattern, suggesting that the impaired glucose tolerance of the corn oil-fed rats had a strong influence on the tissue levels of these eicosanoids.
O R Bunce; S H Abou el-Ela; C D Berdanier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  8     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    1992 Nov-Dec
Date Detail:
Created Date:  1993-02-23     Completed Date:  1993-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  421-5     Citation Subset:  IM    
Department of Pharmacology, University of Georgia, Athens.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / blood,  metabolism
Brain / metabolism
Corn Oil / administration & dosage,  pharmacology
Diabetes Mellitus, Experimental / metabolism*
Diabetes Mellitus, Type 2 / metabolism*
Dietary Fats / administration & dosage*
Dinoprostone / blood,  metabolism
Eicosanoids / blood,  metabolism*
Fish Oils / administration & dosage,  pharmacology
Glucose Tolerance Test
Kidney Medulla / metabolism
Leukotriene B4 / blood,  metabolism
Rats, Mutant Strains
Triglycerides / blood
Reg. No./Substance:
0/Dietary Fats; 0/Eicosanoids; 0/Fish Oils; 0/Triglycerides; 363-24-6/Dinoprostone; 58962-34-8/6-Ketoprostaglandin F1 alpha; 71160-24-2/Leukotriene B4; 8001-30-7/Corn Oil; 8002-50-4/Menhaden oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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