Document Detail

Long-term favourable effect of nifedipine in primary pulmonary hypertension. Report of a case with hemodynamic evaluation after 3 and after 16 months and with clinical follow-up during 36 months.
MedLine Citation:
PMID:  3830769     Owner:  NLM     Status:  MEDLINE    
The favourable effect of long-term (36 months) treatment with nifedipine in a case of primary pulmonary hypertension is described. While clinical improvement was quick, pulmonary hemodynamic data were unchanged after 3 months of treatment, when acute administration of the drug showed a significant fall in pulmonary resistances. After 16 months of treatment a consistent decrease of pulmonary artery pressure was found, suggesting a selective favourable effect of the drug on the pulmonary circulation. The association with systemic arterial hypertension, whose onset was near contemporaneous with pulmonary hypertension, might indicate a common vasoconstrictive pathogenetic mechanism.
R Musante; M Di Donato
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Giornale italiano di cardiologia     Volume:  15     ISSN:  0046-5968     ISO Abbreviation:  G Ital Cardiol     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-05-08     Completed Date:  1986-05-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1270331     Medline TA:  G Ital Cardiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  1110-2     Citation Subset:  IM    
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MeSH Terms
Follow-Up Studies
Heart Catheterization
Hemodynamics / drug effects*
Hypertension, Pulmonary / drug therapy*,  physiopathology
Nifedipine / therapeutic use*
Reg. No./Substance:

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