Document Detail

Long-term exposure to methylmercury and its effects on hypertension in Minamata.
MedLine Citation:
PMID:  19922910     Owner:  NLM     Status:  MEDLINE    
Recent studies suggest potential adverse effects of methylmercury exposure on cardiovascular disease, although the evidence of association with hypertension is still inconsistent. Therefore, we evaluated the effects of methylmercury exposure on hypertension in Minamata. We used data derived from the 1971 population-based survey in Minamata and neighboring communities. We also utilized data on hair mercury content of the participants (derived from a 1960 investigation). We adopted two exposure indices (residential area and hair mercury content) and two hypertension outcomes (past history of hypertension and hypertension defined by measurements in the examination). Then, we estimated the adjusted prevalence odds ratio (POR) and its confidence interval (CI) of both hypertension outcomes in relation to residential area and hair mercury content. In the Minamata area (high exposure area), 87% (833) of the eligible population (aged > or =10 years) participated in the 1971 investigations. In the Goshonoura area (middle exposure area) and the Ariake area (low exposure area), 93% (1450) and 77% (755), respectively, of the eligible population participated. Compared with subjects in the Ariake area, the subjects in the Minamata area manifested hypertension more frequently, and PORs observed for two hypertension outcomes were 1.6 (95% CI: 1.2-2.1) and 1.4 (95% CI: 1.1-1.9), respectively. Furthermore, dose-response trends with hair mercury content were observed for both hypertension outcomes. The present finding supports the causal relationship between methylmercury exposure and hypertension.
Takashi Yorifuji; Toshihide Tsuda; Saori Kashima; Soshi Takao; Masazumi Harada
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental research     Volume:  110     ISSN:  1096-0953     ISO Abbreviation:  Environ. Res.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  40-6     Citation Subset:  IM    
Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
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MeSH Terms
Environmental Exposure / analysis*
Hair / chemistry
Hypertension / chemically induced*,  epidemiology
Japan / epidemiology
Methylmercury Compounds / analysis,  pharmacokinetics,  toxicity*
Middle Aged
Time Factors
Water Pollutants, Chemical / analysis,  pharmacokinetics,  toxicity*
Young Adult
Reg. No./Substance:
0/Methylmercury Compounds; 0/Water Pollutants, Chemical

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