Document Detail

Long-term exposure to indoor air pollution and wheezing symptoms in infants.
MedLine Citation:
PMID:  20028431     Owner:  NLM     Status:  MEDLINE    
Long-term exposure to air pollution is suspected to cause recurrent wheeze in infants. The few previous studies have had ambiguous results. The objective of this study was to estimate the impact of measured long-term exposure to indoor air pollution on wheezing symptoms in infants. We monitored wheezing symptoms in diaries for a birth cohort of 411 infants. We measured long-term exposure to nitrogen oxides (NO(x)), NO(2), formaldehyde, PM(2.5) and black smoke in the infants' bedrooms and analyzed risk associations during the first 18 months of life by logistic regression with the dichotomous end-point 'any symptom-day' (yes/no) and by standard linear regression with the end-point 'number of symptom-days'. The results showed no systematic association between risk for wheezing symptoms and the levels of these air pollutants with various indoor and outdoor sources. In conclusion, we found no evidence of an association between long-term exposure to indoor air pollution and wheezing symptoms in infants, suggesting that indoor air pollution is not causally related to the underlying disease. Practical Implications Nitrogen oxides, formaldehyde and fine particles were measured in the air in infants' bedrooms. The results showed no evidence of an association between long-term exposure and wheezing symptoms in the COPSAC birth cohort.
O Raaschou-Nielsen; M N Hermansen; L Loland; F Buchvald; C B Pipper; M Sørensen; S Loft; H Bisgaard
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-14
Journal Detail:
Title:  Indoor air     Volume:  20     ISSN:  1600-0668     ISO Abbreviation:  Indoor Air     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423515     Medline TA:  Indoor Air     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  159-67     Citation Subset:  IM    
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen Ø, Denmark.
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MeSH Terms
Air Pollution, Indoor / adverse effects*
Infant, Newborn
Inhalation Exposure / adverse effects*
Nitrogen Oxides / adverse effects,  analysis
Prospective Studies
Respiratory Sounds / etiology,  physiopathology*
Time Factors
Reg. No./Substance:
0/Nitrogen Oxides

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