| Long-term exposure to high fat diet is bad for your brain: Exacerbation of focal ischemic brain injury. | |
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MedLine Citation:
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PMID: 21435380 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A diet consisting of high levels of saturated fat has been linked to a dramatic rise in obesity, Type II diabetes and metabolic syndrome. The effect of these co-morbidities on stroke outcome has not been examined in detail in human or animal studies. In this study we hypothesized that maintaining animals on a high fat, 'Western diet' (WD), for an extended period would have a detrimental effect on ischemic outcome. Forty-eight male Sprague Dawley rats were exposed to one month of either WD or control diets initiated at six weeks of age (Experiment 1) or three months of either WD or control diets initiated at four weeks of age (Experiment 2) prior to endothelin-1-induced ischemia. Following ischemia, animals were assessed in the staircase reaching and beam-traversing tests at two and four weeks post-ischemia and infarct volumes were calculated at four weeks post-ischemia. Analysis revealed no difference between animals exposed to either WD or control diets for one month in behavioural or histological assessments. In contrast, three months of WD diet exposure significantly increased functional impairments in both the staircase and beam-traversing tests as well as increasing the volume of infarction, primarily in the cortex. The results of this study demonstrate that long-term exposure to WD diets are detrimental to ischemic outcome. Consequently, it is important to incorporate disease co-morbidities and/or risk factors in preclinical evaluation of neuroprotective or restorative interventions if therapies are to be translated into the clinic. |
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Authors:
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Kristopher D Langdon; Jared Clarke; Dale Corbett |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-21 |
Journal Detail:
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Title: Neuroscience Volume: - ISSN: 1873-7544 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, CANADA A1B 3V6. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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