Document Detail

Long-term experience of surgical treatment for aortic regurgitation attributable to Behçet's disease.
MedLine Citation:
PMID:  19463593     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cardiac involvement in Behçet's disease is a rare but severe complication and presents challenges to cardiac surgeons as a result of late valve detachment or pseudoaneurysms of the aortic root after valve surgery. Few reports have been published on this topic. In this article, clinical data and surgical outcomes in patients with aortic regurgitation attributable to Behçet's disease were analyzed. METHODS: Nineteen patients with aortic regurgitation attributable to Behçet's disease were surgically treated between March 1986 and June 2008. There were 15 men and 4 women with ages ranging from 24 to 55 years (mean, 39 +/- 7 years). Mean follow-up duration from index operations was 77.4 +/- 68.1 months (range, 9 to 271 months). RESULTS: Overall mortality was 47.3% (9 of 19 patients), but no early deaths occurred at index operations. All deaths occurred after second operations, and the causes of death were low cardiac output (n = 6) and sudden aggravation of aortic regurgitation (n = 3). Erythrocyte sedimentation rates and C-reactive protein concentrations were negatively correlated with event-free period. Event-free survival at 13 years was 39.2% +/- 14.1% in patients who underwent aortic root replacement, but this was 4% +/- 3.9% in patients who underwent valve replacement (p = 0.001). Event-free survival at 13 years in patients who were administered immunosuppressive therapies was 33.7% +/- 11.0% and 0% in patients not administered immunosuppressive therapy (p = 0.001). CONCLUSIONS: The mortality in this condition was very high and was found to depend on levels of postoperative inflammatory markers. Aortic root replacement and postoperative immunosuppressive therapy may be helpful.
Dong Seop Jeong; Kyung-Hwan Kim; Jun Sung Kim; Hyun Ahn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  87     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1775-82     Citation Subset:  AIM; IM    
Department of Thoracic and Cardiovascular Surgery, Seoul National University Borame Medical Center, Seoul, South Korea.
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MeSH Terms
Aortic Valve Insufficiency / etiology*,  surgery*
Behcet Syndrome / complications*
Middle Aged
Time Factors
Young Adult
Comment In:
Ann Thorac Surg. 2009 Jun;87(6):1782   [PMID:  19463594 ]

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