Document Detail


Long-term exercise training selectively alters serum cytokines involved in fever.
MedLine Citation:
PMID:  19190031     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-term exercise training selectively alters serum cytokines involved in fever. Chronic exercise training has a number of effects on the immune system that may mimic the physiological response to fever. Female rats that voluntarily exercise on running wheels develop an elevated daytime core temperature after several weeks of training. It remains to be seen whether the elevation in daytime temperature involves inflammatory patterns characteristic of an infectious fever. We assessed whether chronic exercise training in the rat would alter levels of cytokines involved in fever. Female Sprague Dawley rats at 45 days of age weighing 90-110 g were divided into two groups (exercise and sedentary) and housed at an ambient temperature of 22( degrees )C. Interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-alpha), iron, and zinc levels were analyzed. Rats underwent 8 weeks of exercise on running wheels. Exercise led to altered levels of some key cytokines that are involved in fever. Exercise animals had significantly higher IL-1beta levels and lower IL-10 levels compared to sedentary animals. Although IL-6 levels were slightly lower in the exercise animals, these levels were not significantly affected by training. TNF-alpha activity was similar in the two groups. Training also led to a slight increase in serum zinc and decrease in serum unsaturated iron binding capacity (UIBC). The data suggest that chronic exercise training evokes immune responses that mimic some, but not all, aspects of fever. This may explain why exercise leads to elevated daytime core temperature.
Authors:
Pamela Johnson Rowsey; Bonnie L Metzger; John Carlson; Christopher J Gordon
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-02-03
Journal Detail:
Title:  Biological research for nursing     Volume:  10     ISSN:  1099-8004     ISO Abbreviation:  Biol Res Nurs     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-25     Completed Date:  2009-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815758     Medline TA:  Biol Res Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-80     Citation Subset:  IM; N    
Affiliation:
University of North Carolina at Chapel Hill, School of Nursing, Chapel Hill, North Carolina 27599, USA. pjrowsey@unc.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Body Temperature / physiology*
Body Temperature Regulation / physiology
Cytokines / blood*,  immunology
Disease Models, Animal*
Enzyme-Linked Immunosorbent Assay
Female
Fever* / blood,  etiology
Interleukin-10 / blood
Interleukin-1beta / blood
Interleukin-6 / blood
Iron / blood
Iron-Binding Proteins / blood
Nursing Research
Physical Conditioning, Animal / physiology*
Rats
Rats, Sprague-Dawley
Time Factors
Tumor Necrosis Factors / blood
Zinc / blood
Grant Support
ID/Acronym/Agency:
5-RO1-NR04920-01-03/NR/NINR NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interleukin-1beta; 0/Interleukin-6; 0/Iron-Binding Proteins; 0/Tumor Necrosis Factors; 130068-27-8/Interleukin-10; 7439-89-6/Iron; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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