| Long-term evolution of gut inflammation in patients with spondyloarthropathy. | |
| | |
MedLine Citation:
|
PMID: 8964393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: Intestinal inflammation has been observed in patients with spondyloarthropathy (SpA). This prospective study reports the evolution of the intestinal inflammation observed in patients with SpA. METHODS: One hundred twenty-three patients with SpA who had undergone initial endoscopy were clinically reassessed. Intestinal evolution was evaluated by ileocolonoscopy and the histological study of biopsy specimens in 49 patients. RESULTS: Articular remission rates were independent of initial gut inflammation and associated with endoscopic and histological remission. Persistent gut inflammation was observed in active joint disease. Gut inflammation rarely disappeared, despite the persistence of articular complaints. Initial chronic gut inflammation implied a high risk of evolution to ankylosing spondylitis. Evolution to inflammatory bowel disease (IBD) was observed in 7% of patients. Mainly patients with initial chronic inflammation and mild complaints of diarrhea were at risk. Sulfasalazine was more frequently needed in the treatment of patients with gut inflammation with a beneficial effect on articular and intestinal evolution but did not prevent evolution to IBD. CONCLUSIONS: This study supports the etiopathogenetic role of the gut in SpA. Presence of chronic gut inflammation and mild complaints of diarrhea implies a high risk of evolution to ankylosing spondylitis and IBD. Sulfasalazine has a beneficial effect on articular activity by controlling gut inflammation, but it cannot prevent evolution to overt IBD. |
| | |
Authors:
|
M De Vos; H Mielants; C Cuvelier; A Elewaut; E Veys |
Related Documents
:
|
11406333 - Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome. 21404303 - Role of ca-125 in identification of right ventricular failure in chronic obstructive pu... 3510603 - Muscle-contraction headaches in multiple-pain patients: treatment under worsening basel... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Gastroenterology Volume: 110 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1996 Jun |
Date Detail:
|
Created Date: 1996-12-12 Completed Date: 1996-12-12 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1696-703 Citation Subset: AIM; IM |
Affiliation:
|
Department of Gastroenterology, University Hospital Ghent, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Anti-Inflammatory Agents, Non-Steroidal / therapeutic use Disease Progression Enteritis / etiology*, pathology, physiopathology Female Follow-Up Studies Humans Longitudinal Studies Male Middle Aged Prospective Studies Spinal Diseases / complications*, drug therapy, physiopathology Sulfasalazine / therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents, Non-Steroidal; 599-79-1/Sulfasalazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity.
Next Document: A human antibody binds to alpha-galactose receptors and mimics the effects of Clostridium difficile ...