Document Detail

Long-term event-related potential changes following organophosphorus insecticide poisoning.
MedLine Citation:
PMID:  18042425     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine prolonged effects of organophosphorus (OP) insecticide poisoning on cognitive event-related potentials (ERPs).
METHODS: ERPs of a group of 32 patients recovered from cholinergic phase of OP insecticide poisoning were compared with those of two matched control groups: 32 healthy volunteers and nine patients hospitalised with paracetamol overdose. A follow-up assessment was done in 21 patients (66% of the initial sample) 6 months after OP intoxication and the findings were compared with their initial ERP data.
RESULTS: Patients showed highly significant prolongation of P300 latency, compared to healthy controls (p=0.003) and the controls with paracetamol overdose (p=0.016). Follow-up ERP findings of the patients revealed that this impairment remained unchanged even 6 months after OP poisoning (p=0.790). There was no significant difference in N100, P200 and N200 latencies or P300 amplitude either among the groups or between the two assessments of the patients with OP poisoning.
CONCLUSIONS: Our results suggest that acute OP poisoning causes a delay in cognitive processes involved in stimulus classification, lasting at least for 6 months.
SIGNIFICANCE: These findings highlight the possibility of development of long-lasting cognitive deficits following OP insecticide poisoning, and warrant longer-term prospective studies to determine whether this impairment is permanent.
T Dassanayake; V Weerasinghe; U Dangahadeniya; K Kularatne; A Dawson; L Karalliedde; N Senanayake
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-26
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  119     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-04-11     Revised Date:  2013-03-13    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  144-50     Citation Subset:  IM    
Department of Physiology, Faculty of Medicine, Peradeniya 20400, Sri Lanka.
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MeSH Terms
Case-Control Studies
Cognition Disorders / chemically induced,  physiopathology*
Evoked Potentials, Auditory / physiology*
Longitudinal Studies
Neuropsychological Tests
Organophosphate Poisoning*
Poisoning / etiology*,  physiopathology*
Reaction Time / drug effects,  physiology
Retrospective Studies
Grant Support
071669//Wellcome Trust; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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