| Long-term evaluation of single bolus high dose ATG induction therapy for prophylaxis of rejection in live donor kidney transplantation. | |
| | |
MedLine Citation:
|
PMID: 17978857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/AIMS: The long-term evaluation of single bolus high dose antithymocyte globulin (ATG) induction therapy has not been adequately studied. We aimed to evaluate its long-term effects in the living related donor kidney transplantation. METHODS: Eighty adult recipients with their first kidney allograft were randomized into two equal treatment groups, one group received intraoperative single bolus rabbit ATG in a dose of 9 mg/kg and the second group served as a control. All patients were maintained on triple immunosuppressive therapy (steroids, calcineurin inhibitor and antiproliferative agent). We followed them thoroughly for minimum of 5 years. RESULTS: ATG significantly reduced the proportion of patients who experienced acute rejection episodes in the first year (9/40) when compared to the control group (26/40) and in 5 years (11/40) when compared to (30/40) in controls. The cumulative steroid dose used throughout the study was significantly lower in the ATG group. The overall incidence of posttransplant complications was comparable among the two treatment groups. There was no significant difference in patient and graft survival: 5 year survival was 100% and 85% for the ATG group, and 95% and 92.5% in the control group, respectively. CONCLUSION: Although routine single bolus ATG induction significantly reduces the incidence of acute rejection, its long-term beneficial effects on graft function and patient and graft survival are not evident. |
| | |
Authors:
|
Hussein A Sheashaa; Ahmed F Hamdy; Mohamed A Bakr; Sherif F Abdelbaset; Mohamed A Ghoneim |
Related Documents
:
|
11343977 - Tacrolimus versus cyclosporine after lung transplantation: a prospective, open, randomi... 14687467 - Cyclosporine a in treatment of membranous lupus nephropathy. 7740477 - Post-partum factor viii inhibitors. a review of the literature with special reference t... 22744527 - Inclusion criteria for physical therapy intervention studies on scoliosis - a review of... 11343977 - Tacrolimus versus cyclosporine after lung transplantation: a prospective, open, randomi... 15354637 - Prevention of postischemic spinal cord injury by means of regional infusion of adenosin... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: International urology and nephrology Volume: 40 ISSN: 0301-1623 ISO Abbreviation: Int Urol Nephrol Publication Date: 2008 |
Date Detail:
|
Created Date: 2008-08-14 Completed Date: 2008-09-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0262521 Medline TA: Int Urol Nephrol Country: Hungary |
Other Details:
|
Languages: eng Pagination: 515-20 Citation Subset: IM |
Affiliation:
|
Urology & Nephrology Center, Mansoura University, Mansoura, Egypt. drhattia@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antilymphocyte Serum / administration & dosage* Female Glucocorticoids / administration & dosage Graft Rejection / prevention & control* Humans Infusions, Intravenous Kidney Transplantation / immunology* Living Donors Male Methylprednisolone / administration & dosage Plasma Exchange Prospective Studies |
| Chemical | |
Reg. No./Substance:
|
0/Antilymphocyte Serum; 0/Glucocorticoids; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Central venous catheters as a vascular access modality for pediatric hemodialysis.
Next Document: Idiopathic infantile hypercalcemia and renal involvement.