Document Detail

Long-term environmental exposure to perchlorate through drinking water and thyroid function during pregnancy and the neonatal period.
MedLine Citation:
PMID:  16187904     Owner:  NLM     Status:  MEDLINE    
We have conducted a longitudinal epidemiologic study among pregnant women from three cities in northern Chile: Taltal with 114 microg/L, Chañaral with 6 microg/L, and Antofagasta with 0.5 microg/L perchlorate in the public drinking water. We tested the hypothesis that long-term exposure to perchlorate at these levels may cause a situation analogous to iodine deficiency, thus causing increases in thyrotropin (TSH) and thyroglobulin (Tg) levels and decreased levels of free thyroxine (FT4), in either the mother during the early stages of gestation or the neonate at birth, or in the fetus cause growth retardation. We found no increases in Tg or TSH and no decreases in FT4 among either the women during early pregnancy (16.1 +/- 4.1 weeks), late pregnancy (32.4 +/- 3.0 weeks), or the neonates at birth related to perchlorate in drinking water. Neonatal birth weight, length, and head circumference were not different among the three cities and were consistent with current U.S. norms. Therefore, perchlorate in drinking water at 114 microg/L did not cause changes in neonatal thyroid function or fetal growth retardation. Median urinary iodine among the entire cohort was 269 microg/L, intermediate between that of pregnant women in the United States at National Health and Nutrition Examination Survey (NHANES) I and at NHANES III and consistent with current World Health Organization (WHO) recommendations. Median breast milk iodine was not decreased in the cities with detectable perchlorate. Analysis of maternal urinary perchlorate excretion indicates an additional dietary source of perchlorate.
Rafael Téllez Téllez; Patricio Michaud Chacón; Carlos Reyes Abarca; Ben C Blount; Cynthia B Van Landingham; Kenny S Crump; John P Gibbs
Related Documents :
15119494 - Keratosis pilaris in pregnancy: an unrecognized dematosis of pregnancy?
20962514 - Large fetal goiter due to placental passage of maternal antithyroperoxidase antibodies.
23703224 - Role of placental nutrient sensing in developmental programming.
15200964 - Thyroid disease and other endocrine disorders in pregnancy.
21908954 - Successful detection of the fetal electrocardiogram waveform changes during various sta...
1550174 - Does amniotic fluid analysis reflect acid-base balance in fetal blood?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  15     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-28     Completed Date:  2006-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  963-75     Citation Subset:  IM    
Medicine Service, Sótero del Río Hospital, Puente Alto, Chile.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Birth Weight
Cesarean Section / statistics & numerical data
Chile / epidemiology
Environmental Exposure*
Goiter / epidemiology
Health Surveys
Infant, Newborn / physiology*
Iodides / urine
Longitudinal Studies
Milk, Human / chemistry
Perchloric Acid / adverse effects*
Pregnancy / physiology*
Selenium / blood
Thyroid Diseases / chemically induced*,  epidemiology*
Thyroid Function Tests
Thyroid Gland / physiology*,  physiopathology
Thyroid Hormones / blood
Water Supply / analysis*
Reg. No./Substance:
0/Iodides; 0/Thyroid Hormones; 0/perchlorate; 7601-90-3/Perchloric Acid; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Norway rat population in Baltimore, Maryland, 2004.
Next Document:  Variable expression of coxsackie-adenovirus receptor in thyroid tumors: implications for adenoviral ...