| Long-term environmental exposure to perchlorate through drinking water and thyroid function during pregnancy and the neonatal period. | |
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MedLine Citation:
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PMID: 16187904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have conducted a longitudinal epidemiologic study among pregnant women from three cities in northern Chile: Taltal with 114 microg/L, Chañaral with 6 microg/L, and Antofagasta with 0.5 microg/L perchlorate in the public drinking water. We tested the hypothesis that long-term exposure to perchlorate at these levels may cause a situation analogous to iodine deficiency, thus causing increases in thyrotropin (TSH) and thyroglobulin (Tg) levels and decreased levels of free thyroxine (FT4), in either the mother during the early stages of gestation or the neonate at birth, or in the fetus cause growth retardation. We found no increases in Tg or TSH and no decreases in FT4 among either the women during early pregnancy (16.1 +/- 4.1 weeks), late pregnancy (32.4 +/- 3.0 weeks), or the neonates at birth related to perchlorate in drinking water. Neonatal birth weight, length, and head circumference were not different among the three cities and were consistent with current U.S. norms. Therefore, perchlorate in drinking water at 114 microg/L did not cause changes in neonatal thyroid function or fetal growth retardation. Median urinary iodine among the entire cohort was 269 microg/L, intermediate between that of pregnant women in the United States at National Health and Nutrition Examination Survey (NHANES) I and at NHANES III and consistent with current World Health Organization (WHO) recommendations. Median breast milk iodine was not decreased in the cities with detectable perchlorate. Analysis of maternal urinary perchlorate excretion indicates an additional dietary source of perchlorate. |
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Authors:
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Rafael Téllez Téllez; Patricio Michaud Chacón; Carlos Reyes Abarca; Ben C Blount; Cynthia B Van Landingham; Kenny S Crump; John P Gibbs |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: 15 ISSN: 1050-7256 ISO Abbreviation: Thyroid Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-28 Completed Date: 2006-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: United States |
Other Details:
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Languages: eng Pagination: 963-75 Citation Subset: IM |
Affiliation:
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Medicine Service, Sótero del Río Hospital, Puente Alto, Chile. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anthropometry Birth Weight Cesarean Section / statistics & numerical data Chile / epidemiology Environmental Exposure* Female Goiter / epidemiology Health Surveys Humans Infant, Newborn / physiology* Iodides / urine Longitudinal Studies Male Milk, Human / chemistry Perchloric Acid / adverse effects* Pregnancy / physiology* Questionnaires Selenium / blood Thyroid Diseases / chemically induced*, epidemiology* Thyroid Function Tests Thyroid Gland / physiology*, physiopathology Thyroid Hormones / blood Water Supply / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Iodides; 0/Thyroid Hormones; 0/perchlorate; 7601-90-3/Perchloric Acid; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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